Clonal analysis reveals common lineage relationships between head muscles and second heart field derivatives in the mouse embryo

被引:140
作者
Lescroart, Fabienne [1 ]
Kelly, Robert G. [2 ]
Le Garrec, Jean-Francois [1 ]
Nicolas, Jean-Francois [3 ]
Meilhac, Sigolene M. [1 ]
Buckingham, Margaret [1 ]
机构
[1] Inst Pasteur, Unite Genet Mol Dev, CNRS, URA 2578, F-75015 Paris, France
[2] Univ Aix Marseille 2, Dev Biol Inst Marseille Luminy, CNRS, UMR 6216,Inst Paseteur, Marseille, France
[3] CNRS, URA 2578, Unite Biol Mol Dev, F-75015 Paris, France
来源
DEVELOPMENT | 2010年 / 137卷 / 19期
关键词
Retrospective clonal analysis; Head muscles; Second heart field; Mouse; OUTFLOW TRACT; CELL-FATE; PARAXIAL MESODERM; MYOCARDIAL-CELLS; MAMMALIAN HEART; TBX1; DIFFERENTIATION; GASTRULATION; MYOGENESIS; REGIONALIZATION;
D O I
10.1242/dev.050674
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Head muscle progenitors in pharyngeal mesoderm are present in close proximity to cells of the second heart field and show overlapping patterns of gene expression. However, it is not clear whether a single progenitor cell gives rise to both heart and head muscles. We now show that this is the case, using a retrospective clonal analysis in which an nlaacZ sequence, converted to functional nlacZ after a rare intragenic recombination event, is targeted to the. c-actin gene, expressed in all developing skeletal and cardiac muscle. We distinguish two branchiomeric head muscle lineages, which segregate early, both of which also contribute to myocardium. The first gives rise to the temporalis and masseter muscles, which derive from the first branchial arch, and also to the extraocular muscles, thus demonstrating a contribution from paraxial as well as prechordal mesoderm to this anterior muscle group. Unexpectedly, this first lineage also contributes to myocardium of the right ventricle. The second lineage gives rise to muscles of facial expression, which derive from mesoderm of the second branchial arch. It also contributes to outflow tract myocardium at the base of the arteries. Further sublineages distinguish myocardium at the base of the aorta or pulmonary trunk, with a clonal relationship to right or left head muscles, respectively. We thus establish a lineage tree, which we correlate with genetic regulation, and demonstrate a clonal relationship linking groups of head muscles to different parts of the heart, reflecting the posterior movement of the arterial pole during pharyngeal morphogenesis.
引用
收藏
页码:3269 / 3279
页数:11
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