Synthesis, characterization, spectroscopic properties of 2-(4-dimethylaminophenyl)-5-fluoro-6-(morpholin-4-yl)-1H-benzimidazole and its interaction with calf thymus DNA

被引：0
|
作者：
Tang, LT [1 ]
Wang, Y [1 ]
Liu, XQ [1 ]
Hu, SW [1 ]
Chu, TW [1 ]
Wang, XY [1 ]
机构：
[1] Peking Univ, Coll Chem & Mol Engn, Beijing 100871, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2005年 / 16卷 / 03期
关键词：
2-(4-dimethylaminophenyl)-5-fluoro-6-(morpholin-4-yl)-1H-benzimidazole; calf thymus DNA;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
2-(4-Dimethylaniinophenyl)-5-fluoro-6-(morpholin-4-yl)-1H-benzimidazole(1) has been synthesized and characterized by H-1-NMR, MS and elemental analysis. UV-Vis spectra of the aqueous solutions at different pH values reveal that compound I can combine three protons. Its three protonation constants are determined by spectrophotometry and calculated by non-linear least squares. The results of steady-state fluorescence measurements indicate that a special interaction occurs between compound 1 and calf thymus DNA, of which the binding constant, K-b, is (2.30 +/- 0.10)x10(4) L/mol. Compound 1 in the concentration range of 10(-8) to 1.2x10(-6) mol/L could be used for quantitative determination of DNA..
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页码：345 / 348
页数：4
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