The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans

被引：391

作者：

Andreux, Penelope A. ^{[1
]}

Blanco-Bose, William ^{[1
]}

Ryu, Dongryeol ^{[1
,2
,5
]}

Burdet, Frederic ^{[3
]}

Ibberson, Mark ^{[3
]}

Aebischer, Patrick ^{[4
]}

Auwerx, Johan ^{[2
]}

Singh, Anurag ^{[1
]}

Rinsch, Chris ^{[1
]}

机构：

[1] Amazentis SA, EPFL Innovat Pk, Batiment C, Lausanne, Switzerland

[2] Ecole Polytech Fed Lausanne, Lab Integrat & Syst Physiol, Lausanne, Switzerland

[3] SIB Swiss Inst Bioinformat, Vital IT Grp, Batiment Genopode, Lausanne, Switzerland

[4] Ecole Polytech Fed Lausanne, Neurodegenerat Dis Lab, Lausanne, Switzerland

[5] Sungkyunkwan Univ, Sch Med, Dept Mol Cell Biol, Suwon, South Korea

来源：

NATURE METABOLISM | 2019年 / 1卷 / 06期

关键词：

SKELETAL-MUSCLE; ACYLCARNITINES; EXPRESSION; ENERGETICS; AUTOPHAGY;

D O I：

10.1038/s42255-019-0073-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Urolithin A (UA) is a natural dietary, microflora-derived metabolite shown to stimulate mitophagy and improve muscle health in old animals and in preclinical models of aging(1). Here, we report the results of a first-in-human clinical trial in which we administered UA, either as a single dose or as multiple doses over a 4-week period, to healthy, sedentary elderly individuals. We show that UA has a favourable safety profile (primary outcome). UA was bioavailable in plasma at all doses tested, and 4 weeks of treatment with UA at doses of 500 mg and 1,000 mg modulated plasma acylcarnitines and skeletal muscle mitochondrial gene expression in elderly individuals (secondary outcomes). These observed effects on mitochondrial biomarkers show that UA induces a molecular signature of improved mitochondrial and cellular health following regular oral consumption in humans.

引用

页码：595 / 603

页数：9

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