Layer I as a putative neurogenic niche in young adult guinea pig cerebrum

被引：25

作者：

Xiong, Kun ^{[2
]}

Cai, Yan ^{[1
,2
,3
]}

Zhang, Xue-Mei ^{[3
,4
]}

Huang, Ju-Fang ^{[2
]}

Liu, Zhong-Yu ^{[5
]}

Fu, Guang-Ming ^{[5
]}

Feng, Jia-Chun ^{[4
]}

Clough, Richard W. ^{[1
]}

Patrylo, Peter R. ^{[1
,3
]}

Luo, Xue-Gang ^{[2
]}

Hu, Chun-Hong ^{[5
]}

Yan, Xiao-Xin ^{[1
,2
]}

机构：

[1] So Illinois Univ, Sch Med, Dept Anat, Carbondale, IL 62901 USA

[2] Cent S Univ, Xiangya Med Sch, Dept Anat & Neurobiol, Changsha 410013, Hunan, Peoples R China

[3] So Illinois Univ, Sch Med, Dept Physiol, Carbondale, IL 62901 USA

[4] Jilin Univ, Hosp 1, Dept Neurol, Changchun 130021, Jilin, Peoples R China

[5] Cent S Univ, Dept Oncol, Xiangya Hosp 2, Changsha 410011, Hunan, Peoples R China

来源：

MOLECULAR AND CELLULAR NEUROSCIENCE | 2010年 / 45卷 / 02期

关键词：

Marginal zone; Adult neurogenesis; Neuroplasticity; Corticogenesis; Brain evolution; NEWLY GENERATED NEURONS; DOUBLECORTIN EXPRESSION; PIRIFORM CORTEX; SUBVENTRICULAR ZONE; PROGENITOR CELLS; BASAL FOREBRAIN; NEOCORTEX; RAT; POPULATION; MIGRATION;

D O I：

10.1016/j.mcn.2010.06.009

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A considerable number of cells expressing typical immature neuronal markers including doublecortin (DCX+) are present around layer II in the cerebral cortex of young and adult guinea pigs and other larger mammals, and their origin and biological implication await further characterization. We show here in young adult guinea pigs that these DOC+ cells are accompanied by in situ cell division around the superficial cortical layers mostly in layer but they co-express proliferating cell nuclear antigen (PCNA) and an early neuronal fate determining factor, PAX6. A small number of these DOC+ cells also colocalize with BrdU following administration of this mitotic indicator. Cranial X-ray irradiation causes a decline of DCX+ cells around layer II, and novel environmental exploration induces c-Fos expression among these cells in several neocortical areas. Together, these data are compatible with a notion that DCX+ cortical neurons around layer II might derive from proliferable neuronal precursors around layer I in young adult guinea pig cerebrum, and that these cells might be modulated by experience under physiological conditions. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：180 / 191

页数：12

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