An MRI-Based Semiquantitative Index for the Evaluation of Brain Atrophy and Lesions in Alzheimer's Disease, Mild Cognitive Impairment and Normal Aging

被引：19
作者：
Chen, Wei [10 ]
Song, Xiaowei [1 ,2 ]
Zhang, Yunting [10 ]
Darvesh, Sultan [3 ,4 ,7 ]
Zhang, Ningnannan [10 ]
D'Arcy, Ryan C. N. [5 ,6 ]
Black, Sandra [8 ,9 ]
Rockwood, Kenneth [2 ,7 ]
机构：
[1] Natl Res Council Canada, Neuroimaging Res Lab, Inst Biodiagnost Atlantic, Halifax, NS B3H 3A7, Canada
[2] Dalhousie Univ, Dept Med, Div Geriatr Med, Halifax, NS, Canada
[3] Dalhousie Univ, Dept Med Neurol, Halifax, NS, Canada
[4] Dalhousie Univ, Dept Anat & Neurobiol, Halifax, NS, Canada
[5] Dalhousie Univ, Dept Radiol & Psychol, Halifax, NS, Canada
[6] Dalhousie Univ, Dept Neurosci, Halifax, NS, Canada
[7] QEII Hlth Sci Ctr, Ctr Hlth Care Elderly, Halifax, NS, Canada
[8] Univ Toronto, Sunnybrook Hlth Sci Ctr, Dept Med Neurol, Toronto, ON, Canada
[9] Univ Toronto, Sunnybrook Hlth Sci Ctr, Heart & Stroke Fdn, Ctr Stroke Recovery, Toronto, ON, Canada
[10] Tianjin Med Univ, Gen Hosp, Dept Radiol, Tianjin, Peoples R China
来源：
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS | 2010年 / 30卷 / 02期
基金：
美国国家卫生研究院;
关键词：
Aging; Alzheimer's disease; Brain lesions; Brain atrophy; Mild cognitive impairment; TEMPORAL-LOBE ATROPHY; WHITE-MATTER LESIONS; LACUNAR INFARCTS; RATING-SCALE; HYPERINTENSITIES; PROGRESSION; DEMENTIA; HIPPOCAMPAL; SCANS;
D O I：
10.1159/000319537
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Background: This study investigates how T-1-weighted MRI can be used to evaluate brain anatomical changes. We investigated these changes in Alzheimer's disease (AD) and normal aging. Methods: A semiquantitative brain atrophy and lesion index (BALI) was constructed by adapting existing visual rating scales and validated in 3 datasets. Results: The T-1- and T-2-weighted-imaging-based scores were highly correlated. They were both closely associated with age and with cognitive test scores. Conclusion: The T-1-based BALI helps describe brain structural variability in AD, mild cognitive impairment and normal aging. Copyright (C) 2010 S. Karger AG, Basel
引用
收藏
页码：121 / 130
页数：10
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