An MRI-Based Semiquantitative Index for the Evaluation of Brain Atrophy and Lesions in Alzheimer's Disease, Mild Cognitive Impairment and Normal Aging

被引：19

作者：

Chen, Wei ^{[10
]}

Song, Xiaowei ^{[1
,2
]}

Zhang, Yunting ^{[10
]}

Darvesh, Sultan ^{[3
,4
,7
]}

Zhang, Ningnannan ^{[10
]}

D'Arcy, Ryan C. N. ^{[5
,6
]}

Black, Sandra ^{[8
,9
]}

Rockwood, Kenneth ^{[2
,7
]}

机构：

[1] Natl Res Council Canada, Neuroimaging Res Lab, Inst Biodiagnost Atlantic, Halifax, NS B3H 3A7, Canada

[2] Dalhousie Univ, Dept Med, Div Geriatr Med, Halifax, NS, Canada

[3] Dalhousie Univ, Dept Med Neurol, Halifax, NS, Canada

[4] Dalhousie Univ, Dept Anat & Neurobiol, Halifax, NS, Canada

[5] Dalhousie Univ, Dept Radiol & Psychol, Halifax, NS, Canada

[6] Dalhousie Univ, Dept Neurosci, Halifax, NS, Canada

[7] QEII Hlth Sci Ctr, Ctr Hlth Care Elderly, Halifax, NS, Canada

[8] Univ Toronto, Sunnybrook Hlth Sci Ctr, Dept Med Neurol, Toronto, ON, Canada

[9] Univ Toronto, Sunnybrook Hlth Sci Ctr, Heart & Stroke Fdn, Ctr Stroke Recovery, Toronto, ON, Canada

[10] Tianjin Med Univ, Gen Hosp, Dept Radiol, Tianjin, Peoples R China

来源：

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS | 2010年 / 30卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Aging; Alzheimer's disease; Brain lesions; Brain atrophy; Mild cognitive impairment; TEMPORAL-LOBE ATROPHY; WHITE-MATTER LESIONS; LACUNAR INFARCTS; RATING-SCALE; HYPERINTENSITIES; PROGRESSION; DEMENTIA; HIPPOCAMPAL; SCANS;

D O I：

10.1159/000319537

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Background: This study investigates how T-1-weighted MRI can be used to evaluate brain anatomical changes. We investigated these changes in Alzheimer's disease (AD) and normal aging. Methods: A semiquantitative brain atrophy and lesion index (BALI) was constructed by adapting existing visual rating scales and validated in 3 datasets. Results: The T-1- and T-2-weighted-imaging-based scores were highly correlated. They were both closely associated with age and with cognitive test scores. Conclusion: The T-1-based BALI helps describe brain structural variability in AD, mild cognitive impairment and normal aging. Copyright (C) 2010 S. Karger AG, Basel

引用

页码：121 / 130

页数：10

共 31 条

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