Discovery of an angiotensin II binding inhibitor from a Cytospora sp - Using semi-automated screening procedures

被引：14

作者：

StevensMiles, S ^{[1
]}

Goetz, MA ^{[1
]}

Bills, GF ^{[1
]}

Giacobbe, RA ^{[1
]}

Tkacz, JS ^{[1
]}

Chang, RSL ^{[1
]}

Mojena, M ^{[1
]}

Martin, I ^{[1
]}

Diez, MT ^{[1
]}

Pelaez, F ^{[1
]}

Hensens, OD ^{[1
]}

Jones, T ^{[1
]}

Burg, RW ^{[1
]}

Kong, YL ^{[1
]}

Huang, LY ^{[1
]}

机构：

[1] MERCK SHARP & DOHME ESPANA SA,E-28027 MADRID,SPAIN

来源：

JOURNAL OF ANTIBIOTICS | 1996年 / 49卷 / 02期

关键词：

D O I：

10.7164/antibiotics.49.119

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Cytosporin A, B and C, three antagonists of [I-125]-angiotensin II binding to rat adrenal glands were discovered in fermentations of an endophytic Cytospora sp. during routine screening using semi-automated procedures. The most potent of these displayed an IC50 of 1.5 similar to 3 mu M and was specific for angiotensin II AT(2).

引用

页码：119 / 123

页数：5

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