Robust Findings From 25Years of PSTD Genetics Research

被引：37

作者：

Duncan, Laramie E. ^{[1
]}

Cooper, Bryna N. ^{[2
]}

Shen, Hanyang ^{[1
]}

机构：

[1] Stanford Univ, Dept Psychiat & Behav Sci, 401 Quarry Rd,Room 3320, Stanford, CA 94305 USA

[2] PGSP Stanford Psy D Consortium, Palo Alto, CA USA

来源：

CURRENT PSYCHIATRY REPORTS | 2018年 / 20卷 / 12期

关键词：

Posttraumatic stress disorder; PTSD; Genetics; Genome-wide association study; GWAS; Polygenic; POSTTRAUMATIC-STRESS-DISORDER; GENOME-WIDE ASSOCIATION; ENVIRONMENTAL-INFLUENCES; PSYCHIATRIC GENOMICS; NICOTINE DEPENDENCE; ALCOHOL DEPENDENCE; COMBAT EXPOSURE; CANDIDATE GENES; COMPLEX TRAITS; HUMAN-DISEASES;

D O I：

10.1007/s11920-018-0980-1

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Purpose of ReviewThe purpose of this review is to contextualize findings from the first 25years of PTSD genetics research, focusing on the most robust findings and interpreting results in light of principles that have emerged from modern genetics studies.Recent FindingsGenome-wide association studies (GWAS) encompassing tens of thousands of participants enabled the first molecular genetic heritability and genetic correlation estimates for PTSD in 2017. In 2018, highly promising loci for PTSD were reported, including variants in and near the CAMKV, KANSL1, and TCF4 genes.SummaryTwin studies from 25years ago established that PTSD is genetically influenced and foreshadowed the molecular genetic findings of today. Discoveries that were impossible with smaller studies have been achieved via collaborative/team-science efforts. Most promisingly, individual genomic loci offer entirely novel clues about PTSD etiology, providing the raw material for transformative discoveries, and the future of PTSD research is bright.

引用

页数：9

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