Heat shock proteins and aging in Drosophila melanogaster

被引：70
|
作者：
Morrow, G
Tanguay, RM
机构：
[1] Univ Laval, Lab Cellular & Dev Genet, Dept Med, Ste Foy, PQ G1K 7P4, Canada
[2] Univ Laval, CREFSIP, Ste Foy, PQ G1K 7P4, Canada
来源：
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2003年 / 14卷 / 05期
关键词：
aging; oxidative stress; chaperones; Drosophila; sHsp; MITOCHONDRIAL OXIDATIVE STRESS; GENE-EXPRESSION PROFILE; OXYGEN-FREE RADICALS; LIFE-SPAN EXTENSION; MOLECULAR CHAPERONES; LONGEVITY EXTENSION; MALPIGHIAN TUBULES; C-ELEGANS; CELL; HSP27;
D O I：
10.1016/j.semcdb.2003.09.023
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Heat shock proteins (Hsps) are conserved molecular chaperones that are upregulated following exposure to environmental stress and during aging. The mechanisms underlying the aging process are only beginning to be understood. The beneficial effects of Hsps on aging revealed in mild stress and overexpression experiments suggest that these proteins are part of an important cell protection system rather than being unspecific molecular chaperones. Among the Hsps families, small Hsps have the greatest influence on aging and the modulation of their expression during aging in Drosophila suggest that they are involved in pathways of longevity determination. (C) 2003 Elsevier Ltd. All rights reserved.
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收藏
页码：291 / 299
页数：9
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