Heat shock proteins and aging in Drosophila melanogaster

被引：70
作者：
Morrow, G
Tanguay, RM
机构：
[1] Univ Laval, Lab Cellular & Dev Genet, Dept Med, Ste Foy, PQ G1K 7P4, Canada
[2] Univ Laval, CREFSIP, Ste Foy, PQ G1K 7P4, Canada
来源：
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2003年 / 14卷 / 05期
基金：
加拿大健康研究院;
关键词：
aging; oxidative stress; chaperones; Drosophila; sHsp; MITOCHONDRIAL OXIDATIVE STRESS; GENE-EXPRESSION PROFILE; OXYGEN-FREE RADICALS; LIFE-SPAN EXTENSION; MOLECULAR CHAPERONES; LONGEVITY EXTENSION; MALPIGHIAN TUBULES; C-ELEGANS; CELL; HSP27;
D O I：
10.1016/j.semcdb.2003.09.023
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Heat shock proteins (Hsps) are conserved molecular chaperones that are upregulated following exposure to environmental stress and during aging. The mechanisms underlying the aging process are only beginning to be understood. The beneficial effects of Hsps on aging revealed in mild stress and overexpression experiments suggest that these proteins are part of an important cell protection system rather than being unspecific molecular chaperones. Among the Hsps families, small Hsps have the greatest influence on aging and the modulation of their expression during aging in Drosophila suggest that they are involved in pathways of longevity determination. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码：291 / 299
页数：9
相关论文
共 120 条
  • [1] The genome sequence of Drosophila melanogaster
    Adams, MD
    Celniker, SE
    Holt, RA
    Evans, CA
    Gocayne, JD
    Amanatides, PG
    Scherer, SE
    Li, PW
    Hoskins, RA
    Galle, RF
    George, RA
    Lewis, SE
    Richards, S
    Ashburner, M
    Henderson, SN
    Sutton, GG
    Wortman, JR
    Yandell, MD
    Zhang, Q
    Chen, LX
    Brandon, RC
    Rogers, YHC
    Blazej, RG
    Champe, M
    Pfeiffer, BD
    Wan, KH
    Doyle, C
    Baxter, EG
    Helt, G
    Nelson, CR
    Miklos, GLG
    Abril, JF
    Agbayani, A
    An, HJ
    Andrews-Pfannkoch, C
    Baldwin, D
    Ballew, RM
    Basu, A
    Baxendale, J
    Bayraktaroglu, L
    Beasley, EM
    Beeson, KY
    Benos, PV
    Berman, BP
    Bhandari, D
    Bolshakov, S
    Borkova, D
    Botchan, MR
    Bouck, J
    Brokstein, P
    [J]. SCIENCE, 2000, 287 (5461) : 2185 - 2195
  • [2] CHARACTERIZATION OF HSP27 AND 3 IMMUNOLOGICALLY RELATED POLYPEPTIDES DURING DROSOPHILA DEVELOPMENT
    ARRIGO, AP
    PAULI, D
    [J]. EXPERIMENTAL CELL RESEARCH, 1988, 175 (01) : 169 - 183
  • [3] CELLULAR-LOCALIZATION OF HSP23 DURING DROSOPHILA DEVELOPMENT AND FOLLOWING SUBSEQUENT HEAT-SHOCK
    ARRIGO, AP
    [J]. DEVELOPMENTAL BIOLOGY, 1987, 122 (01) : 39 - 48
  • [4] Chaperone suppression of α-synuclein toxicity in a Drosophila model for Parkinson's disease
    Auluck, PK
    Chan, HYE
    Trojanowski, JQ
    Lee, VMY
    Bonini, NM
    [J]. SCIENCE, 2002, 295 (5556) : 865 - 868
  • [5] Chaperoning brain degeneration
    Bonini, NM
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 : 16407 - 16411
  • [6] Neuronal regulation of lifespan: clues from flies and worms
    Boulianne, GL
    [J]. MECHANISMS OF AGEING AND DEVELOPMENT, 2001, 122 (09) : 883 - 894
  • [7] Reassembly and protection of small nuclear ribonucleoprotein particles by heat shock proteins in yeast cells
    Bracken, AP
    Bond, U
    [J]. RNA, 1999, 5 (12) : 1586 - 1596
  • [8] The Hsp70 and Hsp60 chaperone machines
    Bukau, B
    Horwich, AL
    [J]. CELL, 1998, 92 (03) : 351 - 366
  • [9] Hormesis and debilitation effects in stress experiments using the nematode worm Caenorhabditis elegans:: the model of balance between cell damage and HSP levels
    Butov, A
    Johnson, T
    Cypser, J
    Sannikov, I
    Volkov, M
    Sehl, M
    Yashin, A
    [J]. EXPERIMENTAL GERONTOLOGY, 2001, 37 (01) : 57 - 66
  • [10] Genetic modulation of polyglutamine toxicity by protein conjugation pathways in Drosophila
    Chan, HYE
    Warrick, JM
    Andriola, I
    Merry, D
    Bonini, NM
    [J]. HUMAN MOLECULAR GENETICS, 2002, 11 (23) : 2895 - 2904
12345678910