Capillary electrophoretic separation of clomiphene isomers using various cyclodextrins as additives

被引：0

作者：

Juvancz, Z ^{[1
]}

Urmos, I ^{[1
]}

Klebovich, I ^{[1
]}

机构：

[1] EGIS PHARMACEUT,DEPT PHARMACOKINET,H-1106 BUDAPEST,HUNGARY

来源：

JOURNAL OF CAPILLARY ELECTROPHORESIS | 1996年 / 3卷 / 04期

关键词：

separation of cis-trans isomers; cyclodextrin additives; migration reversal; role of organic modifier;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cis (Z) and trans (E) isomers of clomiphene were separated using capillary electrophoresis. Various derivatives of cyclodextrins (CDs) were applied as buffer additives, achieving a resolution of greater than 18. The effect of various parameters, type and concentration of CDs, type and concentration of background electrolytes (BGEs), pH, and organic modifiers has been studied systematically. Migration reversal was observed in several cases. The loadability of the various buffer systems was also taken into account.

引用

页码：181 / 189

页数：9