Fungal Depsides-Naturally Inspiring Molecules: Biosynthesis, Structural Characterization, and Biological Activities

被引：34

作者：

Ibrahim, Sabrin R. M. ^{[1
,2
]}

Sirwi, Alaa ^{[3
]}

Eid, Basma G. ^{[4
]}

Mohamed, Shaimaa G. A. ^{[5
]}

Mohamed, Gamal A. ^{[3
,6
]}

机构：

[1] Batterjee Med Coll, Preparatory Year Program, Jeddah 21442, Saudi Arabia

[2] Assiut Univ, Fac Pharm, Dept Pharmacognosy, Assiut 71526, Egypt

[3] King Abdulaziz Univ, Fac Pharm, Dept Nat Prod & Alternat Med, Jeddah 21589, Saudi Arabia

[4] King Abdulaziz Univ, Fac Pharm, Dept Pharmacol & Toxicol, Jeddah 21589, Saudi Arabia

[5] British Univ, Fac Dent, Suez Desert Rd, El Sherouk 11837, Egypt

[6] Al Azhar Univ, Fac Pharm, Dept Pharmacognosy, Assiut Branch, Assiut 71524, Egypt

来源：

METABOLITES | 2021年 / 11卷 / 10期

关键词：

fungi; depsides; biosynthesis; spectral data; biological activities; CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ALPHA-GLUCOSIDASE INHIBITORS; HUMICOLA SP FO-2942; ENDOPHYTIC FUNGUS; DIACYLGLYCEROL ACYLTRANSFERASE; SECONDARY METABOLITES; THIELOCIN A1-BETA; AMIDEPSINE-B; THIELAVIN-B; CRM646-A;

D O I：

10.3390/metabo11100683

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fungi represent a huge reservoir of structurally diverse bio-metabolites. Although there has been a marked increase in the number of isolated fungal metabolites over the past years, many hidden metabolites still need to be discovered. Depsides are a group of polyketides consisting of two or more ester-linked hydroxybenzoic acid moieties. They possess valuable bioactive properties, such as anticancer, antidiabetic, antibacterial, antiviral, anti-inflammatory, antifungal, antifouling, and antioxidant qualities, as well as various human enzyme-inhibitory activities. This review provides an overview of the reported data on fungal depsides, including their sources, biosynthesis, physical and spectral data, and bioactivities in the period from 1975 to 2020. Overall, 110 metabolites and more than 122 references are confirmed. This is the first review of these multi-faceted metabolites from fungi.

引用

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