Vanilloid and isovanilloid analogues as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases

被引：22

作者：

Lee, J ^{[1
]}

Kang, SU

Kim, SY

Kim, SE

Jo, YJ

Kim, S

机构：

[1] Seoul Natl Univ, Coll Pharm, Med Chem Lab, Kwanak Ku, Seoul 151742, South Korea

[2] Sungkyunkwan Univ, ImaGene Co, Suwon 440746, South Korea

[3] Sungkyunkwan Univ, Natl Creat Res Initiat Ctr ARS Network, Suwon 440746, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(01)00096-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

As aminoacyl adenylate surrogates, a series of methionyl and isoleucyl phenolic analogues containing bioisosteric linkers mimicking ribose have been investigated. Inhibition of synthesized compounds to the aminoacylation reaction b?i the corresponding Escherichia coli methionyl-tRNA and isoleucyl-tRNA synthetases indicated that 18 was found to be a potent inhibitor of isoleucyl-tRNA synthetase. A molecular modeling study demonstrated that in 18. isovanillate and hydroxamate served as proper surrogates for adenine and ribose in isoleucyl adenylate, respectively. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：965 / 968

页数：4

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