Transport according to GARP: receiving retrograde cargo at the trans-Golgi network

被引：112

作者：

Bonifacino, Juan S. ^{[1
]}

Hierro, Aitor ^{[2
]}

机构：

[1] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Cell Biol & Metab Program, NIH, Bethesda, MD 20892 USA

[2] Ctr Cooperat Res Biosci CIC bioGUNE, Struct Biol Unit, Derio 48160, Spain

来源：

TRENDS IN CELL BIOLOGY | 2011年 / 21卷 / 03期

关键词：

MOTOR-NEURON DISEASE; AMYOTROPHIC-LATERAL-SCLEROSIS; VESICLE TETHERING COMPLEXES; SACCHAROMYCES-CEREVISIAE; STRUCTURAL BASIS; EARLY ENDOSOME; SNARE TLG1P; BINDING-PROTEIN; MEMBRANE-FUSION; GENOMIC SCREEN;

D O I：

10.1016/j.tcb.2010.11.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Tethering factors are large protein complexes that capture transport vesicles and enable their fusion with acceptor organelles at different stages of the endomembrane system. Recent studies have shed new light on the structure and function of a heterotetrameric tethering factor named Golgi-associated retrograde protein (GARP), which promotes fusion of endosome-derived, retrograde transport carriers to the trans-Golgi network (TGN). X-ray crystallography of the Vps53 and Vps54 subunits of GARP has revealed that this complex is structurally related to other tethering factors such as the exocyst, the conserved oligomeric Golgi (COG) and Dsl1 (dependence on SLY1-20) complexes, indicating that they all might work by a similar mechanism. Loss of GARP function compromises the growth, fertility and/or viability of the defective organisms, emphasizing the essential nature of GARP-mediated retrograde transport.

引用

页码：159 / 167

页数：9

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