Mechanisms of p53-mediated apoptosis

被引：57
|
作者：
Ding, HF
Fisher, DE
机构：
[1] Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA
[2] Childrens Hosp, Boston, MA 02115 USA
来源：
CRITICAL REVIEWS IN ONCOGENESIS | 1998年 / 9卷 / 01期
关键词：
programmed cell death; caspases; tumor suppressors; tumorigenesis; tumor therapy;
D O I：
10.1615/CritRevOncog.v9.i1.60
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
p53-mediated apoptosis of cells with DNA damage or oncogene overexpression is a major mechanism for its function as a tumor suppressor. Both transcriptionally dependent and transcriptionally independent activities of p53 can play a role in mediating cell death. It appears that p53 can induce apoptosis by multiple pathways in a manner which is regulated in a cell type and signal-specific fashion. Understanding the biochemical mechanisms of p53-dependent apoptosis holds a promise of manipulating these pathways in cancer therapy.
引用
收藏
页码：83 / 98
页数：16
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