Mechanisms of p53-mediated apoptosis

被引：57
作者：
Ding, HF
Fisher, DE
机构：
[1] Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA
[2] Childrens Hosp, Boston, MA 02115 USA
来源：
CRITICAL REVIEWS IN ONCOGENESIS | 1998年 / 9卷 / 01期
关键词：
programmed cell death; caspases; tumor suppressors; tumorigenesis; tumor therapy;
D O I：
10.1615/CritRevOncog.v9.i1.60
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
p53-mediated apoptosis of cells with DNA damage or oncogene overexpression is a major mechanism for its function as a tumor suppressor. Both transcriptionally dependent and transcriptionally independent activities of p53 can play a role in mediating cell death. It appears that p53 can induce apoptosis by multiple pathways in a manner which is regulated in a cell type and signal-specific fashion. Understanding the biochemical mechanisms of p53-dependent apoptosis holds a promise of manipulating these pathways in cancer therapy.
引用
收藏
页码：83 / 98
页数：16
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共 102 条
  • [1] Human ICE/CED-3 protease nomenclature
    Alnemri, ES
    Livingston, DJ
    Nicholson, DW
    Salvesen, G
    Thornberry, NA
    Wong, WW
    Yuan, JY
    [J]. CELL, 1996, 87 (02) : 171 - 171
  • [2] Transcriptional activation by p53, but not induction of the p21 gene, is essential for oncogene-mediated apoptosis
    Attardi, LD
    Lowe, SW
    Brugarolas, J
    Jacks, T
    [J]. EMBO JOURNAL, 1996, 15 (14) : 3693 - 3701
  • [3] BARDEESY N, 1995, CANCER RES, V55, P215
  • [4] A PROTEOLYTIC FRAGMENT FROM THE CENTRAL REGION OF P53 HAS MARKED SEQUENCE-SPECIFIC DNA-BINDING ACTIVITY WHEN GENERATED FROM WILD-TYPE BUT NOT FROM ONCOGENIC MUTANT P53-PROTEIN
    BARGONETTI, J
    MANFREDI, JJ
    CHEN, XB
    MARSHAK, DR
    PRIVES, C
    [J]. GENES & DEVELOPMENT, 1993, 7 (12B) : 2565 - 2574
  • [5] INDUCTION OF THE GROWTH INHIBITOR IGF-BINDING PROTEIN-3 BY P53
    BUCKBINDER, L
    TALBOTT, R
    VELASCOMIGUEL, S
    TAKENAKA, I
    FAHA, B
    SEIZINGER, BR
    KLEY, N
    [J]. NATURE, 1995, 377 (6550) : 646 - 649
  • [6] THE BIOCHEMISTRY OF CELL-DEATH BY APOPTOSIS
    BURSCH, W
    KLEINE, L
    TENNISWOOD, M
    [J]. BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE, 1990, 68 (09): : 1071 - 1074
  • [7] P53-DEPENDENT APOPTOSIS IN THE ABSENCE OF TRANSCRIPTIONAL ACTIVATION OF P53-TARGET GENES
    CAELLES, C
    HELMBERG, A
    KARIN, M
    [J]. NATURE, 1994, 370 (6486) : 220 - 223
  • [8] GROWTH-FACTOR MODULATION OF P53-MEDIATED GROWTH ARREST VERSUS APOPTOSIS
    CANMAN, CE
    GILMER, TM
    COUTTS, SB
    KASTAN, MB
    [J]. GENES & DEVELOPMENT, 1995, 9 (05) : 600 - 611
  • [9] Activation of CPP32 and Mch3 alpha in wild-type p53-induced apoptosis
    Chandler, JM
    Alnemri, ES
    Cohen, GM
    MacFarlane, M
    [J]. BIOCHEMICAL JOURNAL, 1997, 322 : 19 - 23
  • [10] CRYSTAL-STRUCTURE OF A P53 TUMOR-SUPPRESSOR DNA COMPLEX - UNDERSTANDING TUMORIGENIC MUTATIONS
    CHO, YJ
    GORINA, S
    JEFFREY, PD
    PAVLETICH, NP
    [J]. SCIENCE, 1994, 265 (5170) : 346 - 355
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