Estimation of Clinocopathological Correlation and Comparison of Salivary TNF-α among Normal and Post Radiotherapy Patients of Oral cancer-A Cross-Sectional Study

被引:0
作者
Begum, Akifa [1 ]
Sinduja, Palati [1 ]
Priyadharshini, R. [1 ]
Jayaraman, Selvaraj [2 ]
机构
[1] Saveetha Univ, Saveetha Inst Med & Tech Sci, Saveetha Dent Coll & Hosp, Dept Pathol,Dept Pharmacol, Chennai, Tamil Nadu, India
[2] Saveetha Univ, Saveetha Inst Med & Tech Sci, Saveetha Dent Coll & Hosp, Dept Biochem,Dept Pharmacol, Chennai, Tamil Nadu, India
来源
JOURNAL OF RESEARCH IN MEDICAL AND DENTAL SCIENCE | 2021年 / 9卷 / 10期
关键词
Salivary TNF-alpha; Oral cancer; Post radiotherapy; Moderately differentiated squamous cell carcinoma; Widely differentiated squamous cell carcinoma; Innovative technique; NECROSIS-FACTOR-ALPHA; MUCOSITIS; LEVEL; SERUM; HEAD;
D O I
暂无
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Introduction: Tumour Necrosis Factor-Alpha (TNF-alpha) is a member of the TNF receptor (TNF/TNFR) cytokine family. TNF-alpha is mainly involved in the maintenance of the source and homeostasis of the basic immune system, inflammation, and host defence. TNF-alpha is a multifunctional cytokine that plays an important role in diverse and a variety of cellular events such as cell survival, proliferation, differentiation, and death. As a major proinflammatory cytokine, TNF-alpha can act as an endogenous tumor promoter to bridge inflammation and carcinogenesis. Aim: The aim of the present study is to evaluate the efficacy of TNF-alpha as a salivary biomarker in oral cancer. Materials and Methods: An invivo cross-sectional study was conducted on saliva samples of Well differentiated and Moderately differentiated Squamous Cell Carcinoma (WDSCC and MDSCC) patients. Unstimulated saliva was collected from patients and ELISA was run on the samples to determine the TNF-alpha levels. Statistical analysis was performed using SPSS software. The standard curve was plotted using SPSS software version 23. Independent t-test was done to compare the results. Results: The salivary TNF-alpha levels in Moderately Differentiated Squamous Cell Carcinoma (MDSCC) patients was found to be 12.31 +/- 2.5 and the level in Well Differentiated Squamous Cell Carcinoma (WDSCC) patients was found to be 8.023 +/- 1.642. The difference was found to be significant (P<0.05). Conclusion: Salivary TNF-alpha in Moderately Differentiated Squamous Cell Carcinoma (MDSCC) patients was considered higher when compared to Well Differentiated Squamous Cell Carcinoma (WDSCC). Hence salivary TNF-alpha can be used as a biomarker for oral cancer.
引用
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页码:92 / 97
页数:6
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共 43 条
  • [21] Molecular characterisation of csgA gene among ESBL strains of A. baumannii and targeting with essential oil compounds from Azadirachta indica
    Jaisankar, Anu Iswarya
    Girija, A. S. Smiline
    Gunasekaran, Shoba
    Priyadharsini, J. Vijayashree
    [J]. JOURNAL OF KING SAUD UNIVERSITY SCIENCE, 2020, 32 (08) : 3380 - 3387
  • [22] Breast cancer and DDT: putative interactions, associated gene alterations, and molecular pathways
    Jayaseelan, Vijayashree Priyadharsini
    Ramesh, Anita
    Arumugam, Paramasivam
    [J]. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 2021, 28 (21) : 27162 - 27173
  • [23] Emerging role of NET inhibitors in cardiovascular diseases
    Jayaseelan, Vijayashree Priyadharsini
    Paramasivam, Arumugam
    [J]. HYPERTENSION RESEARCH, 2020, 43 (12) : 1459 - 1461
  • [24] Role of Salivary Biomarkers in Oral Cancer Detection
    Khurshid, Zohaib
    Zafar, Muhammad S.
    Khan, Rabia S.
    Najeeb, Shariq
    Slowey, Paul D.
    Rehman, Ihtesham U.
    [J]. ADVANCES IN CLINICAL CHEMISTRY, VOL 86, 2018, 86 : 23 - 70
  • [25] Association of Serum and Salivary Tumor Necrosis Factor-α with Histological Grading in Oral Cancer and its Role in Differentiating Premalignant and Malignant Oral Disease
    Krishnan, Rajkumar
    Thayalan, Dinesh Kumar
    Padmanaban, Rajashree
    Ramadas, Ramya
    Annasamy, Ramesh Kumar
    Anandan, Nirmala
    [J]. ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 2014, 15 (17) : 7141 - 7148
  • [26] Targeting NM23-H1-mediated Inhibition of Tumour Metastasis in Viral Hepatitis with Bioactive Compounds from Ganoderma lucidum: A Computational Study
    Kumar, S. Praveen
    Girija, A. S. Smiline
    Priyadharsini, J. Vijayashree
    [J]. INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2020, 82 (02) : 300 - 305
  • [27] Mateos A, 2019, UTERINE CERVICAL CAN, P141
  • [28] Evaluation of adhesion ofStreptococcus mutans, plaque accumulation on zirconia and stainless steel crowns, and surrounding gingival inflammation in primary molars: randomized controlled trial
    Mathew, Mebin George
    Samuel, S. R.
    Soni, Ashu Jagdish
    Roopa, Korishettar Basavaraj
    [J]. CLINICAL ORAL INVESTIGATIONS, 2020, 24 (09) : 3275 - 3280
  • [29] Targeting Epstein-Barr virus nuclear antigen 1 (EBNA-1) with Murraya koengii bio-compounds: An in-silico approach
    Mathivadani, V
    Girija, A. S. Smiline
    Priyadharsini, J., V
    [J]. ACTA VIROLOGICA, 2020, 64 (01) : 93 - 99
  • [30] Mileshkin L., 2019, UTERINE CERVICAL CAN, P89