Synthesis and activity of novel homodimers of Morita-Baylis-Hillman adducts against Leishmania donovani: A twin drug approach

被引：23
作者：
da Silva, Wagner A. V. [1 ]
Rodrigues, Daniele C. [1 ]
de Oliveira, Ramon G. [1 ]
Mendes, Rhuan K. S. [1 ]
Olegario, Tayna R. [1 ]
Rocha, Juliana C. [2 ]
Keesen, Tatjana S. L. [2 ]
Lima-Junior, Claudio G. [1 ]
Vasconcellos, Mario L. A. A. [1 ]
机构：
[1] Univ Fed Paraiba, Dept Quim, Campus 1, BR-58059900 Joao Pessoa, Paraiba, Brazil
[2] Univ Fed Paraiba, Dept Biotecnol, Campus 1, BR-58059900 Joao Pessoa, Paraiba, Brazil
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2016年 / 26卷 / 18期
关键词：
Morita-Baylis-Hillman adducts; Homodimers; Twin drugs; Leishmania donovani; CONGENERS;
D O I：
10.1016/j.bmcl.2016.07.022
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
It is reported here the synthesis of novel Homodimers 12-19 of Morita-Baylis-Hillman adducts (MBHA) from one-pot Morita-Baylis-Hillman Reaction (MBHR) between aromatic aldehydes as eletrophiles and ethylene glycol diacrylate as Michael acceptor (35-94% yields) using cheap and green conditions. The bioactivities were evaluated against promastigote form of Leishmania donovani. All homodimers showed to be more potent than corresponding monomers. It is worth highlighting that the halogenated homodimers 17 and 18 (0.50 mu M) is almost 400 times more active than the corresponding monomer 10 and 1.24 times more potent than the second-line drug amphotericin B (0.62 mu M). Moreover, the selectivity index to 18 is very high (SIrb > 400) far better than amphotericin B (SIrb = 18.73). This is the first report of twin drugs strategy applied on Morita-Baylis-Hillman adducts. (C) 2016 Elsevier Ltd. All rights reserved.
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页码：4523 / 4526
页数：4
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