A facile one-pot synthesis of 2-(2-pyridyl)quinolines via Povarov reaction

被引：22

作者：

Borel, Carmindo Ribeiro ^{[1
]}

Almeida Barbosa, Luiz Claudio ^{[1
,2
]}

Alvares Maltha, Celia Regina ^{[1
]}

Fernandes, Sergio Antonio ^{[1
]}

机构：

[1] Univ Fed Vicosa, Dept Chem, BR-36570000 Vicosa, MG, Brazil

[2] Univ Fed Minas Gerais, Dept Chem, BR-31270901 Belo Horizonte, MG, Brazil

来源：

TETRAHEDRON LETTERS | 2015年 / 56卷 / 05期

关键词：

Streptonigrin; Pyridylquinoline; Multicomponent reactions; Quinoline synthesis; Povarov reaction; CROSS-COUPLING REACTIONS; STREPTONIGRIN BIOSYNTHESIS; MULTICOMPONENT REACTIONS; ACID; DERIVATIVES; REAGENTS;

D O I：

10.1016/j.tetlet.2014.12.016

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of 2-(2-pyridyl)quinolines was achieved via a three-component Povarov reaction of aromatic aldehydes, anilines, and ethyl vinyl ether under boron trifluoride methyl etherate (BF3 center dot O(CH3)(2)) acid catalysis. The developed methodology for the preparation of 2-(2-pyridyl)quinolines offers several advantages over previous methods including mild reaction conditions, easy work-up, a wide range of substrate applicability, and products in good yields. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：662 / 665

页数：4

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