A novel route to unsymmetrical disubstituted ureas and thioureas by HMPA catalyzed reductive alkylation with trichlorosilane

被引：8

作者：

Ran, Xiaoyun ^{[1
]}

Long, Yan ^{[1
]}

Yang, Sheng ^{[1
]}

Peng, Changjiang ^{[1
]}

Zhang, Yuanyuan ^{[1
]}

Qian, Shan ^{[2
]}

Jiang, Zhenju ^{[1
]}

Zhang, Xiaomei ^{[1
]}

Yang, Lingling ^{[2
]}

Wang, Zhouyu ^{[1
]}

Yu, Xiaoqi ^{[1
]}

机构：

[1] Xihua Univ, Dept Chem, Chengdu 610039, Peoples R China

[2] Xihua Univ, Dept Pharmaceut Engn, Chengdu 610039, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2020年 / 7卷 / 03期

基金：

中国国家自然科学基金;

关键词：

N-SUBSTITUTED UREAS; ONE-POT SYNTHESIS; PRACTICAL SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; ASYMMETRIC REDUCTION; ARYL IMINES; EFFICIENT; AMINES; HYDROSILYLATION; DERIVATIVES;

D O I：

10.1039/c9qo01321k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An HMPA catalyzed reductive alkylation of ureas and thioureas with trichlorosilane under mild reaction conditions has been developed. Both aldehydes and ketones could be used as efficient alkylation reagents in this method to obtain the desired products in moderate to high yields. A variety of di- and trisubsituted ureas and thioureas were easily prepared by this new reductive alkylation method. This protocol exhibits excellent functional group tolerance, chemoselectivity and practicality.

引用

页码：472 / 481

页数：10

共 33 条

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