Synthesis of 2-Aminobenzothiazolomethyl Naphthols Using l-Valine Organocatalyst: An Efficient, Versatile and Biodegradable Catalyst

A simple, practical and scalable approach for the synthesis of 2-aminobenzothiazolomethyl naphthols using one-flask three-component reaction of 2-aminobenzothiazole, substituted aromatic aldehydes and beta-naphthol in water is reported. The reaction is catalyzed by l-valine as non-toxic, green, easily available, cheap, sustainable and biodegradable catalyst. The product formation takes shorter reaction time with good to excellent yield. The method is demonstrated on multi gram level. Easy workup procedure, short reaction time and most importantly environmentally benign are the most outstanding advantages of this procedure.