Light emitting diode irradiation protect against the amyloid beta 25-35 induced apoptosis of PC12 cell in vitro

被引：44

作者：

Duan, R

Zhu, L

Liu, TCY ^{[1
]}

Li, Y

Liu, J

Jiao, JL

Xu, XY

Yao, LB

Liu, SH

机构：

[1] S Carolina Normal Univ, Lab Laser Sports Med, Coll Sports Sci, Guangzhou 516031, GD, Peoples R China

[2] Fourth Mil Med Univ, Dept Biochem, Xian 710032, Peoples R China

[3] Huazhong Univ Sci & Technol, State Key Lab Laser Technol, Wuhan 430074, Peoples R China

[4] Minist Educ China, Key Lab Biomed Photon, Wuhan 430074, Peoples R China

[5] Jinan Univ, Coll Med, TCM Dept, Guangzhou 510632, Peoples R China

[6] S China Normal Univ, Sch Informat & Optoelect Sci & Engn, Guangzhou, Peoples R China

来源：

LASERS IN SURGERY AND MEDICINE | 2003年 / 33卷 / 03期

关键词：

Alzheimer's disease; apoptosis; PC12; cells; light emitting diode;

D O I：

10.1002/lsm.10216

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background and Objectives: Whether light emitting diode (LED) irradiation has effects on "beta-amyloid (Abeta) induced apoptosis," a leading hypothesis of the cause of Alzheimer's disease (AD), or not? Study Design/Materials and Methods: Monolayer cell cultures of PC12 were subjected to Abeta or/and LED irradiation at various intensity. Cell apoptosis was confirmed by morphological criteria, DNA fragmentation assay, and FAScan flow cytometer assay. Results: Treatment of the cells with LED irradiation significantly diminished Abeta induced apoptosis within 24 hours. Conclusions: The LED irradiation, when utilized at power of 0.9W/m(2) and 60 minutes has significantly diminished Abeta induced apoptosis of PC12 cells. (C) 2003 Wiley-Liss, Inc.

引用

页码：199 / 203

页数：5

共 23 条

[1]

ANDERS JJ, 1995, LASERS SURG MED S, V7, P7

[2] Is apoptosis key in Alzheimer's disease? [J].