Protein-Protein Interactions in Transcription: A Fertile Ground for Helix Mimetics

被引：21
|
作者：
Guarracino, Danielle A. [1 ]
Bullock, Brooke N. [1 ]
Arora, Paramjit S. [1 ]
机构：
[1] NYU, Dept Chem, New York, NY 10003 USA
来源：
BIOPOLYMERS | 2011年 / 95卷 / 01期
基金：
美国国家科学基金会; 美国国家卫生研究院;
关键词：
helix mimetics; protein-protein interactions; transcription; HYDROGEN-BOND-SURROGATE; BETA-PEPTIDE INHIBITORS; HIGH-AFFINITY LIGANDS; ALPHA-HELICES; TRANSACTIVATION DOMAIN; SELECTIVE INHIBITORS; P53-HDM2; INTERACTION; EFFICIENT SYNTHESIS; STRUCTURAL BASIS; DRUG DISCOVERY;
D O I：
10.1002/bip.21546
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Designed ligands that inhibit protein-protein interactions involved in gene expression are valuable as reagents for genomics research and as leads for drug discovery efforts. Selective modulation of protein-protein interactions has proven to be a daunting task for synthetic ligands; however, the last decade has seen significant advances in inhibitor design, especially for helical protein interfaces. This review discusses examples of transcriptional complexes targeted by designer helices. (C) 2010 Wiley Periodicals, Inc. Biopolymers 95: 1-7, 2011.
引用
收藏
页码：1 / 7
页数：7
相关论文
共 50 条
  • [1] α-Helix mimetics as inhibitors of protein-protein interactions
    Saraogi, Ishu
    Hamilton, Andrew D.
    BIOCHEMICAL SOCIETY TRANSACTIONS, 2008, 36 : 1414 - 1417
  • [2] Inhibitors of protein-protein interactions: Helix mimetics
    Feng, Jianwen
    Marshall, Garland
    BIOPHYSICAL JOURNAL, 2007, : 204A - 204A
  • [3] Heterocyclic α-helix mimetics for targeting protein-protein interactions
    Biros, Shannon M.
    Moisan, Lionel
    Mann, Enrique
    Carella, Alexandre
    Zhai, Dayong
    Reed, John C.
    Rebek, Julius, Jr.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (16) : 4641 - 4645
  • [4] Converting one-face α-helix mimetics into amphiphilic α-helix mimetics as potent inhibitors of protein-protein interactions
    Shin, Min Hyeon
    Lim, Hyun-Suk
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 251
  • [5] Converting One-Face α-Helix Mimetics into Amphiphilic α-Helix Mimetics as Potent Inhibitors of Protein-Protein Interactions
    Lee, Ji Hoon
    Oh, Misook
    Kim, Hyun Soo
    Lee, Huisun
    Im, Wonpil
    Lim, Hyun-Suk
    ACS COMBINATORIAL SCIENCE, 2016, 18 (01) : 36 - 42
  • [6] Development of alpha-helix mimetics designed to disrupt protein-protein interactions.
    Davies, JM
    Hamilton, AD
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2005, 229 : U208 - U209
  • [7] Disrupting protein-protein interactions with non-peptidic, small molecule α-helix mimetics
    Cummings, Christopher G.
    Hamilton, Andrew D.
    CURRENT OPINION IN CHEMICAL BIOLOGY, 2010, 14 (03) : 341 - 346
  • [8] Spiro-cyclopropane type α-helix/β-strand mimetics targeting protein-protein interactions
    Kuwahara, Tomoki
    Mizuno, Akira
    Fukuda, Hayato
    Watanabe, Mizuki
    Shuto, Satoshi
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2017, 254
  • [9] Development of alpha-helix mimetics designed to disrupt protein-protein interactions.
    Davies, JM
    Hamilton, AD
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2005, 229 : U202 - U203
  • [10] Bombesin, tachykinins and mimetics of protein-protein interactions
    Horwell, DC
    Lainton, JAH
    O'Neill, JA
    Pritchard, MC
    Raphy, J
    MEDICINAL CHEMISTRY INTO THE MILLENNIUM, 2001, (264): : 95 - 100
12345