New approaches targeting brown adipose tissue transplantation as a therapy in obesity

被引:38
|
作者
Carmen Soler-Vazquez, M. [1 ]
Mera, Paula [1 ]
Zagmutt, Sebastian [1 ]
Serra, Dolors [1 ,2 ]
Herrero, Laura [1 ,2 ]
机构
[1] Univ Barcelona, Sch Pharm & Food Sci, IBUB, Dept Biochem & Physiol, E-08028 Barcelona, Spain
[2] Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, E-28029 Madrid, Spain
关键词
Brown adipose tissue; Transplantation; Obesity; MESENCHYMAL STEM-CELLS; COLD-INDUCED THERMOGENESIS; DIET-INDUCED OBESITY; WHITE ADIPOCYTES; INSULIN-RESISTANCE; METABOLIC SYNDROME; BEIGE ADIPOCYTES; ADULT HUMANS; ADAPTIVE THERMOGENESIS; GLUCOSE-HOMEOSTASIS;
D O I
10.1016/j.bcp.2018.07.022
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Brown adipose tissue (BAT) is raising high expectations as a potential target in the fight against metabolic disorders such as obesity and type 2 diabetes. BAT utilizes fuels such as fatty acids to maintain body temperature by uncoupling mitochondrial electron transport to produce heat instead of ATP. This process is called thermogenesis. BAT was considered to be exclusive to rodents and human neonates. However, in the last decade several studies have demonstrated that BAT is not only present but also active in adult humans and that its activity is reduced in several pathological conditions, such as aging, obesity, and diabetes. Thus, tremendous efforts are being made by the scientific community to enhance either BAT mass or activity. Several activators of thermogenesis have been described, such as natriuretic peptides, bone morphogenic proteins, or fibroblast growth factor 21. Furthermore, recent studies have tested a therapeutic approach to directly increase BAT mass by the implantation of either adipocytes or fat tissue, This approach might have an important future in regenerative medicine and in the fight against metabolic disorders. Here, we review the emerging field of BAT transplantation including the various sources of mesenchymal stem cell isolation in rodents and humans and the described metabolic outcomes of adipocyte cell transplantation and BAT transplantation in obesity.
引用
收藏
页码:346 / 355
页数:10
相关论文
共 50 条
  • [21] Human brown adipose tissue: regulation and anti-obesity potential
    Saito, Masayuki
    ENDOCRINE JOURNAL, 2014, 61 (05) : 409 - 416
  • [22] Brown adipose tissue activity as a target for the treatment of obesity/insulin resistance
    Poher, Anne-Laure
    Altirriba, Jordi
    Veyrat-Durebex, Christelle
    Rohner-Jeanrenaud, Francoise
    FRONTIERS IN PHYSIOLOGY, 2015, 6
  • [23] Translational issues in targeting brown adipose tissue thermogenesis for human obesity management
    Dulloo, Abdul G.
    UNDERSTANDING ADIPOGENESIS AND FUNCTIONS OF BROWN FAT, 2013, 1302 : 1 - 10
  • [24] Brown Adipose Tissue-A Therapeutic Target in Obesity?
    Trayhurn, Paul
    FRONTIERS IN PHYSIOLOGY, 2018, 9
  • [25] Immune Modulation of Brown(ing) Adipose Tissue in Obesity
    van den Berg, Susan M.
    van Dam, Andrea D.
    Rensen, Patrick C. N.
    de Winther, Menno P. J.
    Lutgens, Esther
    ENDOCRINE REVIEWS, 2017, 38 (01) : 46 - 68
  • [26] Brown Adipose Tissue: A New Target for Antiobesity Therapy
    Meiliana, Anna
    Ijayal, Andi
    INDONESIAN BIOMEDICAL JOURNAL, 2010, 2 (02): : 4 - 15
  • [27] Brown adipose tissue transplantation as a novel alternative to obesity treatment: a systematic review
    Payab, Moloud
    Abedi, Mina
    Foroughi Heravani, Najmeh
    Hadavandkhani, Mahdieh
    Arabi, Maryam
    Tayanloo-Beik, Akram
    Sheikh Hosseini, Motahareh
    Gerami, Hadis
    Khatami, Fateme
    Larijani, Bagher
    Abdollahi, Mohammad
    Arjmand, Babak
    INTERNATIONAL JOURNAL OF OBESITY, 2021, 45 (01) : 109 - 121
  • [28] Brown adipose tissue: a potential target in the fight against obesity and the metabolic syndrome
    Poekes, Laurence
    Lanthier, Nicolas
    Leclercq, Isabelle A.
    CLINICAL SCIENCE, 2015, 129 (11) : 933 - 949
  • [29] Possible Anti-Obesity Role of Flavonoids Through Brown Adipose Tissue
    Zakkour, Hazal Kucukkaraca
    Yildiran, Hilal
    CLINICAL AND EXPERIMENTAL HEALTH SCIENCES, 2024, 14 (01): : 253 - 263
  • [30] Role of Brown Adipose Tissue in Metabolic Health and Efficacy of Drug Treatment for Obesity
    Markina, Natalia O.
    Matveev, Georgy A.
    Zasypkin, German G.
    Golikova, Tatiana I.
    Ryzhkova, Daria V.
    Kononova, Yulia A.
    Danilov, Sergey D.
    Babenko, Alina Yu.
    JOURNAL OF CLINICAL MEDICINE, 2024, 13 (14)