Inositol treatment of Alzheimer's disease: A double blind, cross-over placebo controlled trial

被引：25
作者：
Barak, Y
Levine, J
Glasman, A
Elizur, A
Belmaker, RH
机构：
[1] ABARBANEL MENTAL HLTH CTR,BAT YAM,ISRAEL
[2] BEN GURION UNIV NEGEV,FAC HLTH SCI,MINIST HLTH MENTAL HLTH CTR,BEER SHEVA,ISRAEL
来源：
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 1996年 / 20卷 / 04期
关键词：
Alzheimer's disease; inositol;
D O I：
10.1016/0278-5846(96)00043-7
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
1 A double-blind controlled crossover trial of 6 gm of inositol daily vs glucose for one month each was carried out in 11 Alzheimer patients. 2 Overall CAMCOG scores showed a trend for greater improvement with inositol that was not significant. 3 Language and orientation improved significantly more on inositol than on placebo. There were no serious side effects. 4 Higher doses of inositol should be studied in Alzheimer's Disease for longer periods..
引用
收藏
页码：729 / 735
页数：7
相关论文
共 15 条
[1]   ALZHEIMERS-DISEASE - A DISORDER OF CORTICAL CHOLINERGIC INNERVATION [J].
COYLE, JT ;
PRICE, DL ;
DELONG, MR .
SCIENCE, 1983, 219 (4589) :1184-1190
[2]   RECEPTOR ACTIVATION AND INOSITOL LIPID HYDROLYSIS IN NEURAL TISSUES [J].
FISHER, SK ;
AGRANOFF, BW .
JOURNAL OF NEUROCHEMISTRY, 1987, 48 (04) :999-1017
[3]   BIOCHEMICAL, BEHAVIORAL, AND CLINICAL-STUDIES OF THE ROLE OF INOSITOL IN LITHIUM TREATMENT AND DEPRESSION [J].
KOFMAN, O ;
BELMAKER, RH .
BIOLOGICAL PSYCHIATRY, 1993, 34 (12) :839-852
[4]   INOSITOL 6 G DAILY MAY BE EFFECTIVE IN DEPRESSION BUT NOT IN SCHIZOPHRENIA [J].
LEVINE, J ;
GONSALVES, M ;
BABUR, I ;
STIER, S ;
ELIZUR, A ;
KOFMAN, O ;
BELMAKER, RH .
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL, 1993, 8 (01) :49-53
[5]   INOSITOL TREATMENT RAISES CSF INOSITOL LEVELS [J].
LEVINE, J ;
RAPAPORT, A ;
LEV, L ;
BERSUDSKY, Y ;
KOFMAN, O ;
BELMAKER, RH ;
SHAPIRO, J ;
AGAM, G .
BRAIN RESEARCH, 1993, 627 (01) :168-170
[6]  
LEVINE J, 1995, AM J PSYCHIAT, V152, P792
[7]  
LEVINE J, 1993, PSYCHOPHARMACOTHERAP, P254
[8]   SEROTONIN, MEMORY, AND THE AGING BRAIN [J].
MCENTEE, WJ ;
CROOK, TH .
PSYCHOPHARMACOLOGY, 1991, 103 (02) :143-149
[9]   ALZHEIMER-DISEASE - DEPICTION OF INCREASED CEREBRAL MYOINOSITOL WITH PROTON MR SPECTROSCOPY [J].
MILLER, BL ;
MOATS, RA ;
SHONK, T ;
ERNST, T ;
WOOLLEY, S ;
ROSS, BD .
RADIOLOGY, 1993, 187 (02) :433-437
[10]  
MOHS RC, 1983, PSYCHOPHARMACOL BULL, V19, P448
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