Curcumin in cell death processes: A challenge for CAM of age-related pathologies

被引：99
作者：
Salvioli, S.
Sikora, E.
Cooper, E. L.
Franceschi, C.
机构：
[1] Univ Bologna, Dept Expt Pathol, I-40126 Bologna, Italy
[2] Univ Bologna, Ctr Interdipartimetale L Galvani, I-40126 Bologna, Italy
[3] ER GenTech Lab, I-44100 Ferrara, Italy
[4] M Nencki Inst Expt Biol, Dept Cellular Biochem, PL-02093 Warsaw, Poland
[5] Univ Calif Los Angeles, David Geffen Sch Med, Lab Comparat Neuroimmunol, Dept Neurobiol, Los Angeles, CA 90095 USA
[6] INRCA Ancona, Dept Gerontol Sci, I-60121 Ancona, Italy
来源：
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2007年 / 4卷 / 02期
关键词：
aging; apoptosis; cancer; curcumin; neurodegenerative diseases; xenohormesis;
D O I：
10.1093/ecam/nem043
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
Curcumin, the yellow pigment from the rhizoma of Curcuma longa, is a widely studied phytochemical which has a variety of biological activities: anti-inflammatory and anti-oxidative. In this review we discuss the biological mechanisms and possible clinical effects of curcumin treatment on cancer therapy, and neuro degenerative diseases such as Alzheimer's Disease, with particular attention to the cell death processes induced by curcumin. Since oxidative stress and inflammation are major determinants of the aging process, we also argue that curcumin can have a more general effect that slows down the rate of aging. Finally, the effects of curcumin can be described as xenohormetic, since it activates a sort of stress response in mammalian cells.
引用
收藏
页码：181 / 190
页数：10
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