Fast racemization and dynamic kinetic resolution of primary benzyl amines

被引：39

作者：

Kim, Yunwoong ^{[1
]}

Park, Jaiwook ^{[1
]}

Kim, Mahn-Joo ^{[1
]}

机构：

[1] Pohang Univ Sci & Technol, Dept Chem, Pohang 790784, South Korea

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 42期

基金：

新加坡国家研究基金会;

关键词：

RADICAL-MEDIATED RACEMIZATION; ENANTIOMERICALLY PURE AMINES; ASYMMETRIC TRANSFORMATIONS; AMBIENT-TEMPERATURE; SECONDARY ALCOHOLS; CATALYTIC RACEMIZATION; CHIRAL AMINES; METAL; EFFICIENT; ENZYMES;

D O I：

10.1016/j.tetlet.2010.08.050

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We prepared a Pd nanocatalyst (average diameter of Pd nanoparticles = 1.73 nm) displaying a remarkable activity for the racemization and dynamic kinetic resolution (DKR) of 1-methylbenzylamine. It was eight times more active than the previous best. The DKR of 1-methylbenzylamine with the Pd nanocatalyst (2 mol %) in the presence of a thermostable lipase (Novozym 435) was complete in 6 h at 70 degrees C. The DKRs of other benzyl amines also proceeded to completion in 6 h under similar conditions except the amount of Pd nanocatalyst. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：5581 / 5584

页数：4

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