Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice

被引：560

作者：

Ayala, Julio E. ^{[1
,2
]}

Samuel, Varman T. ^{[3
]}

Morton, Gregory J. ^{[4
]}

Obici, Silvana ^{[5
]}

Croniger, Colleen M. ^{[6
]}

Shulman, Gerald I. ^{[3
]}

Wasserman, David H. ^{[1
]}

McGuinness, Owen P. ^{[1
]}

机构：

[1] Vanderbilt NIH Mouse Metab Phenotyping Ctr, Nashville, TN 37232 USA

[2] Sanford Burnham Med Res Inst Lake Nona, Orlando, FL 32827 USA

[3] Yale NIH Mouse Metab Phenotyping Ctr, New Haven, CT 06520 USA

[4] Univ Washington, NIH Mouse Metab Phenotyping Ctr, Seattle, WA 98109 USA

[5] Univ Cincinnati, NIH Mouse Metab Phenotyping Ctr, Cincinnati, OH 45267 USA

[6] Case Western Reserve Univ, NIH Mouse Metab Phenotyping Ctr, Cleveland, OH 44106 USA

来源：

DISEASE MODELS & MECHANISMS | 2010年 / 3卷 / 9-10期

关键词：

MUSCLE INSULIN SENSITIVITY; DIET-INDUCED OBESITY; HIGH-FAT-DIET; OB-OB MICE; IN-VIVO; SKELETAL-MUSCLE; RECEPTOR SUBSTRATE-1; LIPOATROPHIC MICE; TRANSGENIC MICE; BLOOD-GLUCOSE;

D O I：

10.1242/dmm.006239

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The Mouse Metabolic Phenotyping Center (MMPC) Consortium was established to address the need to characterize the growing number of mouse models of metabolic diseases, particularly diabetes and obesity. A goal of the MMPC Consortium is to propose standard methods for assessing metabolic phenotypes in mice. In this article, we discuss issues pertaining to the design and performance of various tests of glucose metabolism. We also propose guidelines for the description of methods, presentation of data and interpretation of results. The recommendations presented in this article are based on the experience of the MMPC Consortium and other investigators.

引用

页码：525 / 534

页数：10

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