Plumieride exerts anxiolytic-like effect mediated by GABAergic and monoaminergic systems

被引：5

作者：

Dalmagro, Ana Paula ^{[1
]}

Camargo, Anderson ^{[3
]}

Zimath, Priscila Laiz ^{[1
]}

Bonomini, Tiago Jose ^{[1
]}

Zeni, Ana Lucia Bertarello ^{[2
]}

Malheiros, Angela ^{[1
]}

de Souza, Marcia Maria ^{[1
]}

机构：

[1] Univ Vale Itajai Univ, Programa Posgrad Ciencias Farmaceut, Nucleo Invest Quim Farmaceut NIQFAR, Itajai, SC, Brazil

[2] Univ Reg Blumenau FURB, Lab Avaliacao Subst Bioat, Dept Ciencias Nat, Blumenau, SC, Brazil

[3] Univ Fed Santa Catarina, Programa Posgrad Neurociencias, Ctr Ciencias Biol, Florianopolis, SC, Brazil

来源：

NATURAL PRODUCT RESEARCH | 2021年 / 35卷 / 22期

关键词：

Plumieride; iridoid; anxiolytic; monoaminergic; GABAergic;

D O I：

10.1080/14786419.2020.1737052

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Plumieride (PLU), an iridoid isolated from Allamanda cathartica flowers, has been studied by our research group due to its anti-inflammatory potential, antidepressant-like and anxiolytic-like effects. This research investigated the involvement of GABAergic and monoaminergic systems in the anxiolytic-like effect elicited by PLU. Therefore, mice were pre-treated with GABAergic, serotonergic, adrenergic or dopaminergic receptor antagonists (i.p.), and exposed to Elevated Plus-Maze (EPM) and Open-Field Test (OFT). The preliminary results revealed that PLU (p.o.) possibly interacts with the mentioned systems through the GABA(A), GABA(B), 5-HT1A, 5-HT3, alpha(1), alpha(2), and D-2 receptors.

引用

页码：4849 / 4852

页数：4

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