Altered Levels of Visinin-Like Protein 1 Correspond to Regional Neuronal Loss in Alzheimer Disease and Frontotemporal Lobar Degeneration

被引：14

作者：

Kirkwood, Caitlin M. ^{[1
,2
,6
]}

MacDonald, Matthew L. ^{[1
,2
,5
]}

Schempf, Tadhg A. ^{[1
,2
]}

Vatsavayi, Anil V. ^{[9
]}

Ikonomovic, Milos D. ^{[2
,3
,8
]}

Koppel, Jeremy L. ^{[10
,11
,12
]}

Ding, Ying ^{[5
]}

Sun, Mai ^{[5
]}

Kofler, Julia K. ^{[4
]}

Lopez, Oscar L. ^{[2
,3
]}

Yates, Nathan A. ^{[5
,6
]}

Sweet, Robert A. ^{[1
,2
,3
,7
]}

机构：

[1] Univ Pittsburgh, Sch Hlth Sci, Translat Neurosci Program, Pittsburgh, PA USA

[2] Univ Pittsburgh, Dept Psychiat, Sch Hlth Sci, Pittsburgh, PA USA

[3] Univ Pittsburgh, Dept Neurol, Sch Hlth Sci, Pittsburgh, PA 15260 USA

[4] Univ Pittsburgh, Dept Pathol, Sch Hlth Sci, Pittsburgh, PA USA

[5] Univ Pittsburgh, Biomed Mass Spectrometry Ctr, Sch Hlth Sci, Pittsburgh, PA USA

[6] Univ Pittsburgh, Dept Cell Biol, Sch Hlth Sci, Pittsburgh, PA USA

[7] VA Pittsburgh Healthcare Syst, Mental Illness Res Educ & Clin Ctr, Pittsburgh, PA USA

[8] VA Pittsburgh Healthcare Syst, Geriatr Res Educ & Clin Ctr, Pittsburgh, PA USA

[9] Univ Massachusetts, Sch Med, Dept Psychiat, Worcester, MA 01655 USA

[10] Litwin Zucker Res Ctr Study Alzheimers Dis, Manhasset, NY USA

[11] Feinstein Inst Med Res, Manhasset, NY USA

[12] North Shore LIJ Hlth Syst, Zucker Hillside Hosp, Glen Oaks, NY USA

来源：

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY | 2016年 / 75卷 / 02期

关键词：

Alzheimer disease; Frontotemporal lobar degeneration; Human postmortem brain tissue; Visinin-like 1 protein (Vilip-1); CEREBROSPINAL-FLUID; COGNITIVE DECLINE; TANGLE FORMATION; BRAIN-INJURY; LEWY BODIES; BIOMARKER; DEMENTIA; CONSORTIUM; PATHOLOGY; VILIP-1;

D O I：

10.1093/jnen/nlv018

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Recent studies have implicated the neuronal calcium-sensing protein visinin-like 1 protein (Vilip-1) as a peripheral biomarker in Alzheimer disease (AD), but little is known about expression of Vilip-1 in the brains of patients with AD. We used targeted and quantitative mass spectrometry to measure Vilip-1 peptide levels in the entorhinal cortex (ERC) and the superior frontal gyrus (SF) from cases with early to moderate stage AD, frontotemporal lobar degeneration (FTLD), and cognitively and neuropathologically normal elderly controls. We found that Vilip-1 levels were significantly lower in the ERC, but not in SF, of AD subjects compared to normal controls. In FTLD cases, Vilip-1 levels in the SF were significantly lower than in normal controls. These findings suggest a unique role for cerebrospinal fluid Vilip-1 as a biomarker of ERC neuron loss in AD.

引用

页码：175 / 182

页数：8

共 41 条

[1] Tau-mediated neurodegeneration in Alzheimer's disease and related disorders [J].

Ballatore, Carlo ;

Lee, Virginia M. -Y. ;

Trojanowski, John Q. .

NATURE REVIEWS NEUROSCIENCE, 2007, 8 (09) :663-672

[2] Regional and cellular distribution of neural visinin-like protein immunoreactivities (VILIP-1 and VILIP-3) in human brain [J].

Bernstein, HG ;

Baumann, B ;

Danos, P ;

Diekmann, S ;

Bogerts, B ;

Gundelfinger, ED ;

Braunewell, KH .

JOURNAL OF NEUROCYTOLOGY, 1999, 28 (08) :655-662

[3] Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry [J].

Braak, Heiko ;

Alafuzoff, Irina ;

Arzberger, Thomas ;

Kretzschmar, Hans ;

Del Tredici, Kelly .

ACTA NEUROPATHOLOGICA, 2006, 112 (04) :389-404

[4] Abnormal localization of two neuronal calcium sensor proteins, visinin-like proteins (VILIPs)-1 and -3, in neocortical brain areas of Alzheimer disease patients [J].

Braunewell, KH ;

Riederer, P ;

Spilker, C ;

Gundelfinger, ED ;

Bogerts, B ;

Bernstein, HG .

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 2001, 12 (02) :110-116

[5] Stereologic analysis of neurofibrillary tangle formation in prefrontal cortex area 9 in aging and Alzheimer's disease [J].

Bussière, T ;

Gold, G ;

Kövari, E ;

Giannakopoulos, P ;

Bouras, C ;

Perl, DP ;

Morrison, JH ;

Hof, PR .

NEUROSCIENCE, 2003, 117 (03) :577-592

[6] Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration [J].

Cairns, Nigel J. ;

Bigio, Eileen H. ;

Mackenzie, Ian R. A. ;

Neumann, Manuela ;

Lee, Virginia M. -Y. ;

Hatanpaa, Kimmo J. ;

White, Charles L., III ;

Schneider, Julie A. ;

Grinberg, Lea Tenenholz ;

Halliday, Glenda ;

Duyckaerts, Charles ;

Lowe, James S. ;

Holm, Ida E. ;

Tolnay, Markus ;

Okamoto, Koichi ;

Yokoo, Hideaki ;

Murayama, Shigeo ;

Woulfe, John ;

Munoz, David G. ;

Dickson, Dennis W. ;

Ince, Paul G. ;

Trojanowski, John Q. ;

Mann, David M. A. .

ACTA NEUROPATHOLOGICA, 2007, 114 (01) :5-22

[7] Neuronal loss in familial frontotemporal dementia with ubiquitin-positive, tau-negative inclusions [J].

Cairns, NJ ;

Brännström, T ;

Khan, MN ;

Rossor, MN ;

Lantos, PL .

EXPERIMENTAL NEUROLOGY, 2003, 181 (02) :319-326

[8]

Dehmelt L, 2005, GENOME BIOL, V6

[9] Longitudinal Change in CSF Biomarkers in Autosomal-Dominant Alzheimer's Disease [J].

Fagan, Anne M. ;

Xiong, Chengjie ;

Jasielec, Mateusz S. ;

Bateman, Randall J. ;

Goate, Alison M. ;

Benzinger, Tammie L. S. ;

Ghetti, Bernardino ;

Martins, Ralph N. ;

Masters, Colin L. ;

Mayeux, Richard ;

Ringman, John M. ;

Rossor, Martin N. ;

Salloway, Stephen ;

Schofield, Peter R. ;

Sperling, Reisa A. ;

Marcus, Daniel ;

Cairns, Nigel J. ;

Buckles, Virginia D. ;

Ladenson, Jack H. ;

Morris, John C. ;

Holtzman, David M. .

SCIENCE TRANSLATIONAL MEDICINE, 2014, 6 (226)

[10] Distinct patterns of neuronal loss and Alzheimer's disease lesion distribution in elderly individuals older than 90 years [J].

Giannakopoulos, P ;

Hof, PR ;

Kovari, E ;

Vallet, PG ;

Herrmann, FR ;

Bouras, C .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1996, 55 (12) :1210-1220

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