Hereditary Genodermatoses with Cancer Predisposition

被引：12

作者：

Gerstenblith, Meg R. ^{[1
]}

Goldstein, Alisa M. ^{[1
]}

Tucker, Margaret A. ^{[1
]}

机构：

[1] NCI, Genet Epidemiol Branch, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2010年 / 24卷 / 05期

关键词：

Genodermatoses; Nevoid basal cell carcinoma syndrome; Neurofibromatosis type 1; Neurofibromatosis type 2; Tuberous sclerosis; Melanoma; Xeroderma pigmentosum; Dyskeratosis congenita; TUBEROUS SCLEROSIS COMPLEX; BASAL-CELL CARCINOMA; BILATERAL ACOUSTIC NEUROFIBROMATOSIS; GENOTYPE-PHENOTYPE CORRELATIONS; MELANOMA-PRONE FAMILIES; POPULATION-BASED PREVALENCE; POLYCYSTIC KIDNEY-DISEASE; GENOME-WIDE ASSOCIATION; GERM-LINE MUTATIONS; CDKN2A MUTATIONS;

D O I：

10.1016/j.hoc.2010.06.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this article hereditary genodermatoses with cancer predisposition are reviewed, including nevoid basal cell carcinoma syndrome, neurofibromatosis types 1 and 2, tuberous sclerosis complex, xeroderma pigmentosum, and dyskeratosis congenita. Hereditary melanoma is also included, though it differs from the others in several respects. The underlying genetic aberrations causing these syndromes are largely known, allowing novel treatments to be developed for some of these disorders. Early recognition and diagnosis allows for close follow-up and surveillance for associated malignancies.

引用

页码：885 / +

页数：23

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