Synthetic and Nanotechnological Approaches for a Diagnostic Use of Manganese

被引:6
作者
Sguizzato, Maddalena [1 ,2 ]
Martini, Petra [3 ,4 ]
Marvelli, Lorenza [1 ]
Pula, Walter [1 ]
Drechsler, Markus [5 ]
Capozza, Martina [6 ]
Terreno, Enzo [6 ]
Del Bianco, Lucia [7 ]
Spizzo, Federico [7 ]
Cortesi, Rita [1 ,4 ]
Boschi, Alessandra [1 ]
机构
[1] Univ Ferrara, Dept Chem Pharmaceut & Agr Sci DoCPAS, I-44121 Ferrara, Italy
[2] Univ Ferrara, Biotechnol Interuniv Consortium, Ferrara Sect, I-44121 Ferrara, Italy
[3] Univ Ferrara, Dept Environm & Prevent Sci, I-44121 Ferrara, Italy
[4] Ist Nazl Fis Nucl, Lab Nazl Legnaro, Viale Univ 2, I-35020 Legnaro, Italy
[5] Univ Bayreuth, Bavarian Polymer Inst BPI, Key Lab Electron & Opt Microscopy, D-95440 Bayreuth, Germany
[6] Univ Torino, Mol & Preclin Imaging Ctr, Dept Mol Biotechnol & Hlth Sci, I-10126 Turin, Italy
[7] Univ Ferrara, Dept Phys & Earth Sci, I-44122 Ferrara, Italy
来源
MOLECULES | 2022年 / 27卷 / 10期
关键词
lipid-based nanosystems; liposomes; manganese; PET; MRI; magnetic susceptibility; LIPOSOMES; DELIVERY; DISPERSIONS; COMPLEXES;
D O I
10.3390/molecules27103124
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The development of multimodal imaging techniques such as positron emission tomography (PET) and magnetic resonance imaging (MRI) allows the contemporary obtaining of metabolic and morphological information. To fully exploit the complementarity of the two imaging modalities, the design of probes displaying radioactive and magnetic properties at the same time could be very beneficial. In this regard, transition metals offer appealing options, with manganese representing an ideal candidate. As nanosized imaging probes have demonstrated great value for designing advanced diagnostic/theranostic procedures, this work focuses on the potential of liposomal formulations loaded with a new synthesized paramagnetic Mn(II) chelates. Negatively charged liposomes were produced by thin-layer hydration method and extrusion. The obtained formulations were characterized in terms of size, surface charge, efficiency of encapsulation, stability over time, relaxivity, effective magnetic moment, and in vitro antiproliferative effect on human cells by means of the MTT assay. The negatively charged paramagnetic liposomes were monodisperse, with an average hydrodynamic diameter not exceeding 200 nm, and they displayed good stability and no cytotoxicity. As determined by optical emission spectroscopy, manganese complexes are loaded almost completely on liposomes maintaining their paramagnetic properties.
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页数:16
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