Synthesis of trinorditerpenoid derivatives and evaluation of antimicrobial and cytotoxic activity

被引：0
|
作者：
Alonso, R [1 ]
Gomis, H [1 ]
Taddei, A [1 ]
Sajo, C [1 ]
机构：
[1] USB, Dept Biol Celular, Caracas 1080 A, Venezuela
来源：
CHEMISTRY OF NATURAL COMPOUNDS | 2005年 / 41卷 / 03期
关键词：
trinorditerpenoid derivatives; antimicrobial and cytotoxic activity;
D O I：
10.1007/s10600-005-0139-2
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The synthesis of optically active trinorditerpenes was carried out, and their antimicrobial and antitumor activity was tested. The synthetic derivative 12-hydroxypodocarpa-8,11,13-triene (7) showed GI(50) at 6.6 mu M against breast cancer MDA-MB-435 (LC50 = 50.9 mu M and log 10 GI(50) = -5.18). The 12-aceryloxypodocarpa-8,11,13-triene (8) showed GI(50) at 12.1 mu M against leukemia RPMI-8226 (LC50 = 76.1 mu M and log(10) GI(50) = -4.92).
引用
收藏
页码：315 / 321
页数：7
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