Sex differences and hormonal effects on gut microbiota composition in mice

被引：552

作者：

Org, Elin ^{[1
,2
]}

Mehrabian, Margarete ^{[1
]}

Parks, Brian W. ^{[1
,3
]}

Shipkova, Petia ^{[4
]}

Liu, Xiaoqin ^{[5
]}

Drake, Thomas A. ^{[6
]}

Lusis, Aldons J. ^{[1
,7
,8
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Div Cardiol, Los Angeles, CA 90024 USA

[2] Univ Tartu, Estonian Genome Ctr, Tartu, Estonia

[3] Univ Wisconsin, Dept Nutrit Sci, Madison, WI USA

[4] Bristol Myers Squibb, Dept Bioanalyt & Discovery Analyt Sci, Princeton, NJ USA

[5] Bristol Myers Squibb, Dept Cardiovasc Drug Discovery Biol, Princeton, NJ USA

[6] Univ Calif Los Angeles, Dept Pathol & Lab Med, Los Angeles, CA 90024 USA

[7] Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90024 USA

[8] Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90024 USA

来源：

GUT MICROBES | 2016年 / 7卷 / 04期

基金：

美国国家卫生研究院;

关键词：

genetics; gut microbiota interactions; hormones; inbred strains; sex-by-diet interactions; sex differences;

D O I：

10.1080/19490976.2016.1203502

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

We previously reported quantitation of gut microbiota in a panel of 89 different inbred strains of mice, and we now examine the question of sex differences in microbiota composition. When the total population of 689 mice was examined together, several taxa exhibited significant differences in abundance between sexes but a larger number of differences were observed at the single strain level, suggesting that sex differences can be obscured by host genetics and environmental factors. We also examined a subset of mice on chow and high fat diets and observed sex-by-diet interactions. We further investigated the sex differences using gonadectomized and hormone treated mice from 3 different inbred strains. Principal coordinate analysis with unweighted UniFrac distances revealed very clear effects of gonadectomy and hormone replacement on microbiota composition in all 3 strains. Moreover, bile acid analyses showed gender-specific differences as well as effects of gonodectomy, providing one possible mechanism mediating sex differences in microbiota composition.

引用

页码：313 / 322

页数：10

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