MPL immunohistochemical expression as a novel marker for essential thrombocythemia and primary myelofibrosis differential diagnosis

被引：3

作者：

Ponce, Cesar Cilento ^{[1
]}

Chauffaille, Maria de Lourdes F. ^{[2
]}

Ihara, Silvia Saiuli M. ^{[1
]}

Silva, Maria Regina R. ^{[1
]}

机构：

[1] Univ Fed Sao Paulo, Dept Pathol, Sao Paulo, Brazil

[2] Univ Fed Sao Paulo, Dept Hematol, Sao Paulo, Brazil

来源：

LEUKEMIA RESEARCH | 2012年 / 36卷 / 01期

基金：

巴西圣保罗研究基金会;

关键词：

Thrombopoietin receptor (MPL); Megakaryocytes; Primary myelofibrosis; Essential thrombocythemia; Immunohistochemistry; Fibrosis; MEGAKARYOCYTE C-MPL; MYELOPROLIFERATIVE DISORDERS; POLYCYTHEMIA-VERA; SILVER IMPREGNATION; STROMAL CELLS; THROMBOPOIETIN; TGF-BETA-1; RETICULUM; CRITERIA; RECEPTOR;

D O I：

10.1016/j.leukres.2011.06.024

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To evaluate the grading of fibrosis and immunohistochemical expression of MPL in bone marrow biopsies of ET and PMF. Fibrosis in bone marrow biopsies (BMBs) was evaluated according to the European Consensus for grading of fibrosis, according to reticulin proliferation. Immunohistochemical analysis was performed in samples from 18 ET and 38 PMF patients: 19 were classified as pre-fibrotic and 19 were classified as fibrotic according to the World Health Organization (WHO) criteria, by means of the MPL antibody. Six bone marrow donors' biopsies were used as controls. Average reticulin (p < 0.003) and MPL (p < 0.008) values differed significantly between the ET group and the pre-fibrotic stage PMF group. The MPL immunohistochemical expression may represent a new marker for differential diagnosis between ET and pre-fibrotic stage PMF. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：93 / 97

页数：5

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