The genetics of Kawasaki disease

被引：101

作者：

Onouchi, Yoshihiro ^{[1
]}

机构：

[1] Chiba Univ, Grad Sch Med, Dept Publ Hlth, Chiba, Japan

来源：

INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES | 2018年 / 21卷 / 01期

关键词：

genetic variants; Kawasaki disease; susceptibility gene; GENOME-WIDE ASSOCIATION; SYSTEMIC-LUPUS-ERYTHEMATOSUS; CORONARY-ARTERY ANEURYSMS; SUSCEPTIBILITY LOCUS; VARIANTS; LINKAGE; TAIWAN; FAMILY;

D O I：

10.1111/1756-185X.13218

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Kawasaki disease (KD) is a complex disorder which affects genetically susceptible infants and children. Several susceptibility genes (e.g., ITPKC, CASP3, CD40 and ORAI) and chromosomal regions have been identified through genome-wide association and genome-wide linkage studies to have association with KD. Knowledge of susceptibility genes involved in the pathogenesis of KD may provide new insights into diagnosis and treatment of this condition. However, there is much that we still do not know about the genetic basis of KD.

引用

页码：26 / 30

页数：5

共 40 条

[1] Study protocol for a phase III multicentre, randomised, open-label, blinded-end point trial to evaluate the efficacy and safety of immunoglobulin plus cyclosporin A in patients with severe Kawasaki disease (KAICA Trial) [J].

Aoyagi, Reiko ;

Hamada, Hiromichi ;

Sato, Yasunori ;

Suzuki, Hiroyuki ;

Onouchi, Yoshihiro ;

Ebata, Ryota ;

Nagashima, Kengo ;

Terauchi, Moe ;

Terai, Masaru ;

Hanaoka, Hideki ;

Hata, Akira .

BMJ OPEN, 2015, 5 (12)

[2] KAWASAKI SYNDROME IN THE UNITED-STATES - 1976 TO 1980 [J].

BELL, DM ;

MORENS, DM ;

HOLMAN, RC ;

HURWITZ, ES ;

HUNTER, MK .

AMERICAN JOURNAL OF DISEASES OF CHILDREN, 1983, 137 (03) :211-214

[3] A Genome-Wide Association Study Identifies Novel and Functionally Related Susceptibility Loci for Kawasaki Disease [J].

Burgner, David ;

Davila, Sonia ;

Breunis, Willemijn B. ;

Ng, Sarah B. ;

Li, Yi ;

Bonnard, Carine ;

Ling, Ling ;

Wright, Victoria J. ;

Thalamuthu, Anbupalam ;

Odam, Miranda ;

Shimizu, Chisato ;

Burns, Jane C. ;

Levin, Michael ;

Kuijpers, Taco W. ;

Hibberd, Martin L. .

PLOS GENETICS, 2009, 5 (01)

[4] Family-based association analysis implicates IL-4 in susceptibility to Kawasaki disease [J].

Burns, JC ;

Shimizu, C ;

Shike, H ;

Newburger, JW ;

Sundel, RP ;

Baker, AL ;

Matsubara, T ;

Ishikawa, Y ;

Brophy, VA ;

Cheng, S ;

Grow, MA ;

Steiner, LL ;

Kono, N ;

Cantor, R .

GENES AND IMMUNITY, 2005, 6 (05) :438-444

[5] Replication and Meta-Analysis of GWAS Identified Susceptibility Loci in Kawasaki Disease Confirm the Importance of B Lymphoid Tyrosine Kinase (BLK) in Disease Susceptibility [J].

Chang, Chia-Jung ;

Kuo, Ho-Chang ;

Chang, Jeng-Sheng ;

Lee, Jong-Keuk ;

Tsai, Fuu-Jen ;

Khor, Chiea Chuen ;

Chang, Li-Ching ;

Chen, Shih-Ping ;

Ko, Tai-Ming ;

Liu, Yi-Min ;

Chen, Ying-Ju ;

Hong, Young Mi ;

Jang, Gi Young ;

Hibberd, Martin L. ;

Kuijpers, Taco ;

Burgner, David ;

Levin, Michael ;

Burns, Jane C. ;

Davila, Sonia ;

Chen, Yuan-Tsong ;

Chen, Chien-Hsiun ;

Wu, Jer-Yuarn ;

Lee, Yi-Ching .

PLOS ONE, 2013, 8 (08)

[6] Familial occurrence of Kawasaki syndrome in North America [J].

Dergun, M ;

Kao, A ;

Hauger, SB ;

Newburger, JW ;

Burns, JC .

ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE, 2005, 159 (09) :876-881

[7] Genetic and epigenetic fine mapping of causal autoimmune disease variants [J].

Farh, Kyle Kai-How ;

Marson, Alexander ;

Zhu, Jiang ;

Kleinewietfeld, Markus ;

Housley, William J. ;

Beik, Samantha ;

Shoresh, Noam ;

Whitton, Holly ;

Ryan, Russell J. H. ;

Shishkin, Alexander A. ;

Hatan, Meital ;

Carrasco-Alfonso, Marlene J. ;

Mayer, Dita ;

Luckey, C. John ;

Patsopoulos, Nikolaos A. ;

De Jager, Philip L. ;

Kuchroo, Vijay K. ;

Epstein, Charles B. ;

Daly, Mark J. ;

Hafler, David A. ;

Bernstein, Bradley E. .

NATURE, 2015, 518 (7539) :337-343

[8] The MS Risk Allele of CD40 Is Associated with Reduced Cell-Membrane Bound Expression in Antigen Presenting Cells: Implications for Gene Function [J].

Field, Judith ;

Shahijanian, Fernando ;

Schibeci, Stephen ;

Johnson, Laura ;

Gresle, Melissa ;

Laverick, Louise ;

Parnell, Grant ;

Stewart, Graeme ;

McKay, Fiona ;

Kilpatrick, Trevor ;

Butzkueven, Helmut ;

Booth, David .

PLOS ONE, 2015, 10 (06)

[9]

FUJITA Y, 1989, PEDIATRICS, V84, P666

[10] REL, encoding a member of the NF-κB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis [J].

Gregersen, Peter K. ;

Amos, Chistopher I. ;

Lee, Annette T. ;

Lu, Yue ;

Remmers, Elaine F. ;

Kastner, Daniel L. ;

Seldin, Michael F. ;

Criswell, Lindsey A. ;

Plenge, Robert M. ;

Holers, V. Michael ;

Mikuls, Ted R. ;

Sokka, Tuulikki ;

Moreland, Larry W. ;

Bridges, S. Louis, Jr. ;

Xie, Gang ;

Begovich, Ann B. ;

Siminovitch, Katherine A. .

NATURE GENETICS, 2009, 41 (07) :820-U77

← 1 2 3 4 →