Solubilities of zopiclone and nimodipine in supercritical carbon dioxide

被引：33
|
作者：
Medina, I [1 ]
Bueno, JL [1 ]
机构：
[1] Univ Oviedo, Dept Ingn Quim & TMA, E-33071 Oviedo, Spain
来源：
JOURNAL OF CHEMICAL AND ENGINEERING DATA | 2001年 / 46卷 / 05期
关键词：
D O I：
10.1021/je010025t
中图分类号：
O414.1 [热力学];
学科分类号：
摘要：
Solubility measurements for two pharmaceutical products, zopiclone and nimodipine, in supercritical carbon dioxide are reported over the temperature range (313 to 333) K and pressure range (10.0 to 25.0) MPa. The solubilities were measured using a continuous flow apparatus. The measured mole fractions of the two compounds in supercritical carbon dioxide are correlated with the density of the pure solvent, and the solubilities are correlated using the model proposed by Chrastil.
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页码：1211 / 1214
页数：4
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