Nanoparticles-Mediated CRISPR/Cas Gene Editing Delivery System

被引：8

作者：

Saw, Phei Er ^{[1
]}

Cui, Guo-Hui ^{[2
]}

Xu, Xiaoding ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangdong Hong Kong Joint Lab RNA Med, Guangdong Prov Key Lab Malignant Tumor Epigenet &, 107 Yanjiang West Rd, Guangzhou, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Zhongshan Sch Med, South China Natl Biosafety Lab, 74 Zhongshan 2nd Rd, Guangzhou, Guangdong, Peoples R China

来源：

CHEMMEDCHEM | 2022年 / 17卷 / 09期

基金：

中国国家自然科学基金;

关键词：

CRISPR; Cas; gene editing; gene therapy; nanoparticles; CRISPR-CAS9; SYSTEM; CHEMICAL-MODIFICATION; DNA; OPTIMIZATION; ENABLES; RELEASE; CELLS;

D O I：

10.1002/cmdc.202100777

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

CRISPR/Cas system has become one of the most powerful techologies in biomedical research, and has showed great potentials in the gene related diseases. However, efficient delivery systems of CRISPR/Cas to target cells remains challenging. In recent years, nanoparticles have showned great potentials for the delivery of CRISPR/Cas systems. This paper mainly approaches the development and new strategies of CRISPR/Cas delivery systems, as well as their application in the clinical diseases. By summarizing the CRISPR/Cas systems delivery, new strategies are expected for the gene therapy.

引用

页数：10

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