Reduced expression of the BRCA1 gene and increased chromosomal instability in MCF-7 cell line

被引：8

作者：

Kachhap, SK

Vetale, SP

Dange, P

Ghosh, SN ^{[1
]}

机构：

[1] Tata Mem Ctr, Canc Res Inst, Div Cell Biol, Parel 400012, Mumbai, India

[2] Tata Mem Ctr, Canc Res Inst, Div Immunol, Parel, Mumbai, India

来源：

CELL BIOLOGY INTERNATIONAL | 2001年 / 25卷 / 06期

关键词：

breast cancer cell line; BRCA1 mRNA expression; chromosomal instability;

D O I：

10.1006/cbir.2000.0657

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Using clonal cell cultures, a significant increase in chromosomal aberrations (aneuplolidy, dicentrics and chromatid breaks) were observed in MCF-7 cells compared with HeLa. BRCA1 expression was lower in MCF-7 cells than in HeLa cells. Since BRCA1 is known to play a role in the maintenance of chromosomal integrity, the increase in chromosomal aberrations in MCF-7 clones suggests that downregulation of BRCA1 expression could be one of the possible mechanisms for increased chromosomal instability in this cell line. (C) 2001 Academic Press.

引用

页码：547 / 551

页数：5

共 15 条

[1]

COUCH FJ, 1997, NEW ENGL J MED, V336, P1448

[2] Genetic instability of cancer cells is proportional to their degree of aneuploidy [J].