The incidence of type 1 diabetes mellitus among 15-34 years aged Lithuanian population: 18-year incidence study based on prospective databases

被引:16
作者
Ostrauskas, Rytas [1 ]
Zalinkevicius, Rimantas [1 ]
Jurgeviciene, Nijole [1 ]
Radzeviciene, Lina [1 ]
Lasaite, Lina [1 ]
机构
[1] Lithuanian Univ Hlth Sci, Inst Endocrinol, LT-50009 Kaunas, Lithuania
关键词
YOUNG-ADULTS; INCREASING INCIDENCE; SEX-HORMONES; TIME TRENDS; ONSET; CHILDREN; SWEDEN; COUNTRIES; GENETICS; ETIOLOGY;
D O I
10.1186/1471-2458-11-813
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Background: The aim of this prospective study was to determine the incidence of type 1 diabetes mellitus in 15-34-year-aged Lithuanian males and females during 1991 - 2008 Methods: A contact system with general practitioners covering 100% of the 15-34-year-aged Lithuanian population was the primary data source. Reports from regional endocrinologists and statistical note-marks of State patient insurance fund served as secondary sources for case ascertainment. Results: The average age-standardized incidence rate was 8.30 per 100,000 persons per year (95% Poisson distribution confidence interval [CI] 7.90-8.71) during 1991 - 2008 and was statistically significantly higher among males (10.44 per 100,000 persons per year, 95% CI 9.82-11.10) in comparison with females (6.10 per 100,000, 95% CI 5.62-6.62). Male/female rate ratio was 1.71 (95% CI 1.63-1.80). Results of the linear 1991 - 2008 regression model showed that the incidence of Type 1 diabetes in 15-34-year-aged males and females decreased slightly over the time (r = -0.215, p > 0.05). Conclusions: Our data demonstrated the male predominance in primary incidence of type 1 diabetes mellitus in 15-34-year-aged population in Lithuania. The incidence of type 1 diabetes mellitus in 15-34-year-aged males and females decreased slightly during 1991-2008.
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页数:10
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