Pd-Catalyzed Decarboxylative Coupling of Propiolic Adds: One-Pot Synthesis of 1,4-Disubstituted 1,3-Diynes via Sonogashira-Homocoupling Sequence

被引：82

作者：

Park, Jihye ^{[1
]}

Park, Eonjeong ^{[1
]}

Kim, Aejin ^{[1
]}

Park, Seul-A ^{[1
]}

Lee, Youngil ^{[1
]}

Chi, Ki-Whan ^{[1
]}

Jung, Young Hoon ^{[2
]}

Kim, In Su ^{[1
]}

机构：

[1] Univ Ulsan, Dept Chem, Ulsan 680749, South Korea

[2] Sungkyunkwan Univ, Sch Pharm, Suwon 440746, South Korea

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 76卷 / 07期

基金：

新加坡国家研究基金会;

关键词：

ALKYNYL CARBOXYLIC-ACIDS; POTASSIUM POLYFLUOROBENZOATES; CONJUGATED OLIGOMERS; DIRECT ARYLATION; BENZOIC-ACIDS; ARYL; PANAXYTRIOL; HALIDES; KETONES;

D O I：

10.1021/jo200096x

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

One-pot synthesis of symmetric 1,4-disubstituted 1,3-diynes from iodoarenes and propiolic acid via Sonogashira reaction followed by Pd-catalyzed decarboxylative homocouplirtg is developed in high yields. Also, this system allows the one-pot synthesis of unsymmetric 1,4-disubstituted 1,3-diynes by cross-coupling of two different 3-substituted propiolic acids.

引用

页码：2214 / 2219

页数：6

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