A risk factor analysis for local recurrence of bone and soft tissue sarcoma treated with carbon ion radiotherapy: A retrospective cohort study at a single institution

Aim Carbon ion radiotherapy is well-recognized as an excellent radiation modality that is suitable for treating unresectable bone and soft-tissue sarcoma of the trunk, spine, and pelvis; however, further study is needed to improve the local control rate. The current study examined the risk factors of the local recurrence of sarcomas after carbon ion radiotherapy. Methods Patients with inoperable bone and soft-tissue sarcomas treated with carbon ion radiotherapy in our institute from 2010 to 2018 were retrospectively analyzed. Among them, 87 patients were eligible for this study. We divided the instances of local recurrence into two types, in-field and out-field recurrence, and evaluated the predictors for the risk of local recurrence such as the age at the treatment, sex, histopathological diagnosis, standard uptake value on fluorodeoxyglucose positron emission tomography, and the clinical target volume for each recurrence using a Cox proportional hazards model. Results A multivariate analysis revealed that the tumors with a post-treatment standard uptake value of more than 3.84 on positron emission tomography had a significantly high risk of in-field recurrence (hazard ratio, 3.42; p = .03). Furthermore, postoperative lesions were a risk factor for out-field recurrence (hazard ratio, 3.82; p < .01). Conclusion The current study revealed that sarcomas maintaining a high glucose metabolic activity after carbon ion radiotherapy carried a risk of in-field recurrence, and the most significant risk factor of out-field recurrence was identified to be surgery before CIRT.