Discovering drugs to treat coronavirus disease 2019 (COVID-19)

被引：861

作者：

Dong, Liying ^{[1
]}

Hu, Shasha ^{[2
]}

Gao, Jianjun ^{[1
]}

机构：

[1] Qingdao Univ, Sch Pharm, Dept Pharmacol, Qingdao, Shandong, Peoples R China

[2] Qingdao Univ, Affiliated Hosp, Dept Pathol, Qingdao, Shandong, Peoples R China

来源：

DRUG DISCOVERIES AND THERAPEUTICS | 2020年 / 14卷 / 01期

关键词：

novel coronavirus; pneumonia; COVID-19; 2019-nCoV; SARS-CoV-2; SARS;

D O I：

10.5582/ddt.2020.01012

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The SARS-CoV-2 virus emerged in December 2019 and then spread rapidly worldwide, particularly to China, Japan, and South Korea. Scientists are endeavoring to find antivirals specific to the virus. Several drugs such as chloroquine, arbidol, remdesivir, and favipiravir are currently undergoing clinical studies to test their efficacy and safety in the treatment of coronavirus disease 2019 (COVID-19) in China; some promising results have been achieved thus far. This article summarizes agents with potential efficacy against SARS-CoV-2.

引用

页码：58 / 60

页数：3

共 12 条

[1]

[Anonymous], 2020, BIORXIV

[2]

[Anonymous], JOINT RES TEAM SHANG

[3] Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings [J].

Chu, CM ;

Cheng, VCC ;

Hung, IFN ;

Wong, MML ;

Chan, KH ;

Chan, KS ;

Kao, RYT ;

Poon, LLM ;

Wong, CLP ;

Guan, Y ;

Peiris, JSM ;

Yuen, KY .

THORAX, 2004, 59 (03) :252-256

[4] Abelson Kinase Inhibitors Are Potent Inhibitors of Severe Acute Respiratory Syndrome Coronavirus and Middle East Respiratory Syndrome Coronavirus Fusion [J].

Coleman, Christopher M. ;

Sisk, Jeanne M. ;

Mingo, Rebecca M. ;

Nelson, Elizabeth A. ;

White, Judith M. ;

Frieman, Matthew B. .

JOURNAL OF VIROLOGY, 2016, 90 (19) :8924-8933

[5] Favipiravir as a potential countermeasure against neglected and emerging RNA viruses [J].

Delang, Leen ;

Abdelnabi, Rana ;

Neyts, Johan .

ANTIVIRAL RESEARCH, 2018, 153 :85-94

[6] Favipiravir (T-705), a broad spectrum inhibitor of viral RNA polymerase [J].

Furuta, Yousuke ;

Komeno, Takashi ;

Nakamura, Takaaki .

PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES, 2017, 93 (07) :449-463

[7] First Case of 2019 Novel Coronavirus in the United States [J].

Holshue, Michelle L. ;

DeBolt, Chas ;

Lindquist, Scott ;

Lofy, Kathy H. ;

Wiesman, John ;

Bruce, Hollianne ;

Spitters, Christopher ;

Ericson, Keith ;

Wilkerson, Sara ;

Tural, Ahmet ;

Diaz, George ;

Cohn, Amanda ;

Fox, LeAnne ;

Patel, Anita ;

Gerber, Susan I. ;

Kim, Lindsay ;

Tong, Suxiang ;

Lu, Xiaoyan ;

Lindstrom, Steve ;

Pallansch, Mark A. ;

Weldon, William C. ;

Biggs, Holly M. ;

Uyeki, Timothy M. ;

Pillai, Satish K. .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 382 (10) :929-936

[8]

Min Wang, 2020, 2020 11th International Conference on Prognostics and System Health Management (PHM-2020 Jinan), P1, DOI 10.1109/PHM-Jinan48558.2020.00008

[9] New insights into the antiviral effects of chloroquine [J].

Savarino, A ;

Di Trani, L ;

Donatelli, I ;

Cauda, R ;

Cassone, A .

LANCET INFECTIOUS DISEASES, 2006, 6 (02) :67-69

[10] Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV [J].

Sheahan, Timothy P. ;

Sims, Amy C. ;

Leist, Sarah R. ;

Schafer, Alexandra ;

Won, John ;

Brown, Ariane J. ;

Montgomery, Stephanie A. ;

Hogg, Alison ;

Babusis, Darius ;

Clarke, Michael O. ;

Spahn, Jamie E. ;

Bauer, Laura ;

Sellers, Scott ;

Porter, Danielle ;

Feng, Joy Y. ;

Cihlar, Tomas ;

Jordan, Robert ;

Denison, Mark R. ;

Baric, Ralph S. .

NATURE COMMUNICATIONS, 2020, 11 (01)

← 1 2 →