Quantitative in-vivo imaging of the lung using time-domain fluorescence measurements

被引：0
|
作者：
Ma, Guobin [1 ]
Jean-Jacques, Muriel [1 ]
Melanson-Drapeau, Lysanne [1 ]
Khayat, Mario [1 ]
机构：
[1] ART Adv Res Technol Inc, St Laurent, PQ H4S 2A4, Canada
来源：
FLUORESCENCE IN VIVO IMAGING BASED ON GENETICALLY ENGINEERED PROBES: FROM LIVING CELLS TO WHOLE BODY IMAGING IV | 2009年 / 7191卷
关键词：
small animal imaging; in vivo imaging; fluorescence imaging; fluorescence lifetime; optical diffusion; biomedical imaging; molecular imaging; DIFFUSION-APPROXIMATION; PHOTON MIGRATION; TOMOGRAPHY; CETUXIMAB; REFLECTANCE; MEDIA;
D O I：
10.1117/12.809448
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
In this paper, nebulized or intravenous cetuximab (also known as Erbitux) labeled with NIR dyes is administered in the lungs of the mouse and imaged using a time-domain fluorescence imaging system (Optix (R)). Time resolved measurements provide lifetime of the fluorescent probes. In addition, through time-of-flight information contained in the data, one can also assess probe localization and concentration distribution quantitatively. Results shown include suppression of tissue autofluorescence by lifetime gating and recovery of targeted and non-targeted distributions of cetuximab labeled with the NIR fluorophores.
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页数：7
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