From control to eradication of malaria: the end of being stuck in second gear?

被引：14
作者：
Amina, Khadjavi [1 ]
Giuliana, Giribaldi [1 ]
Mauro, Prato [1 ]
机构：
[1] Univ Turin, Sch Med, Dept Genet Biol & Biochem, I-10126 Turin, Italy
来源：
ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE | 2010年 / 3卷 / 05期
关键词：
Malaria; Plasmodium falciparum; Anopheles mosquito; Antimalarial drugs; Vaccine; Vector control; Hemozoin; Matrix metalloproteinases; TRANSMISSION-BLOCKING VACCINE; PLASMODIUM-FALCIPARUM INFECTION; HUMAN ADHERENT MONOCYTES; NECROSIS-FACTOR-ALPHA; IN-VITRO; ARTEMISININ RESISTANCE; KNOCKDOWN RESISTANCE; DRUG-RESISTANCE; VIVAX MALARIA; ANTIMALARIAL;
D O I：
10.1016/S1995-7645(10)60101-0
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
More than 2 billion people are at risk of malaria, which primarily affects poor populations in tropical and subtropical areas, including Southern Asia. As malaria incidence has been reduced strongly in some parts of endemic regions by combinations of interventions, including artemisinin based therapies and insecticide treated bed nets, a new goal has been established recently by charity foundations which support research on malaria: the worldwide eradication of the pathology. Doing away with control approaches which have been applied for the last 50 years and more focus on elimination objectives will deeply change priorities in the area of malaria treatment, chemoprevention, vector control, vaccine research and health system assessment. In this review, actual knowledge on pathogenesis and pharmacology is discussed, and new drugs, vaccines and insecticides are described.
引用
收藏
页码：412 / 420
页数：9
相关论文
共 88 条
[1]   Host cell traversal is important for progression of the malaria parasite through the dermis to the liver [J].
Amino, Rogerio ;
Giovannini, Donatella ;
Thiberge, Sabine ;
Gueirard, Pascale ;
Boisson, Bertrand ;
Dubremetz, Jean-Francois ;
Prevost, Marie-Christine ;
Ishino, Tomoko ;
Yuda, Masao ;
Menard, Robert .
CELL HOST & MICROBE, 2008, 3 (02) :88-96
[2]  
ARESE P, 2007, J INFECTION, V54, P111
[3]   Genetic Mapping of the Duffy Binding Protein (DBP) Ligand Domain of Plasmodium vivax from Unstable Malaria Region in the Middle East [J].
Babaeekho, Laleh ;
Zakeri, Sedigheh ;
Djadid, Navid Dinparast .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2009, 80 (01) :112-118
[4]   Prevention and treatment of vivax malaria [J].
Baird J.K. ;
Schwartz E. ;
Hoffman S.L. .
Current Infectious Disease Reports, 2007, 9 (1) :39-46
[5]   A brief illustrated guide to the ultrastructure of Plasmodium falciparum asexual blood stages [J].
Bannister, LH ;
Hopkins, JM ;
Fowler, RE ;
Krishna, S ;
Mitchell, GH .
PARASITOLOGY TODAY, 2000, 16 (10) :427-433
[6]   Invasion by P-falciparum merozoites suggests a hierarchy of molecular interactions [J].
Baum, Jake ;
Maier, Alexander G. ;
Good, Robert T. ;
Simpson, Ken M. ;
Cowman, Alan F. .
PLOS PATHOGENS, 2005, 1 (04) :299-309
[7]   Efficacy of RTS,S/ASO2 malaria vaccine against Plasmodium falciparum infection in semi-immune adult men in The Gambia:: a randomised trial [J].
Bojang, KA ;
Milligan, PJM ;
Pinder, M ;
Vigneron, L ;
Alloueche, A ;
Kester, KE ;
Ballou, WR ;
Conway, DJ ;
Reece, WHH ;
Gothard, P ;
Yamuah, L ;
Delchambre, M ;
Voss, G ;
Greenwood, BM ;
Hill, A ;
McAdam, KPWJ ;
Tornieporth, N ;
Cohen, JD ;
Doherty, T .
LANCET, 2001, 358 (9297) :1927-1934
[8]   Short-course regimens of artesunate-fosmidomycin in treatment of uncomplicated Plasmodium falciparum malaria [J].
Borrmann, S ;
Adegnika, AA ;
Moussavou, F ;
Oyakhirome, S ;
Esser, G ;
Matsiegui, PB ;
Ramharter, M ;
Lundgren, I ;
Kombila, M ;
Issifou, S ;
Hutchinson, D ;
Wiesner, J ;
Jomaa, H ;
Kremsner, PG .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (09) :3749-3754
[9]   Stereoselectivity in the pharmacodynamics and pharmacokinetics of the chiral antimalarial drugs [J].
Brocks, DR ;
Mehvar, R .
CLINICAL PHARMACOKINETICS, 2003, 42 (15) :1359-1382
[10]   HIGH-DOSE OF PRIMAQUINE IN PRIMAQUINE RESISTANT VIVAX MALARIA [J].
BUNNAG, D ;
KARBWANG, J ;
THANAVIBUL, A ;
CHITTAMAS, S ;
RATANAPONGSE, Y ;
CHALERMRUT, K ;
BANGCHANG, KN ;
HARINASUTA, T .
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1994, 88 (02) :218-219
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