Acute interstitial nephritis associated with ulcerative colitis

被引：17

作者：

Tokuyama, Hirobumi ^{[1
]}

Wakino, Shu ^{[1
]}

Konishi, Konosuke ^{[1
]}

Hashiguchi, Akinori ^{[2
]}

Hayashi, Koichi ^{[1
]}

Itoh, Hiroshi ^{[1
]}

机构：

[1] Keio Univ, Sch Med, Dept Internal Med, Shinjuku Ku, Tokyo 1608582, Japan

[2] Keio Univ, Sch Med, Dept Pathol, Tokyo 1608582, Japan

来源：

CLINICAL AND EXPERIMENTAL NEPHROLOGY | 2010年 / 14卷 / 05期

关键词：

Ulcerative colitis; Acute interstitial nephritis; CD3-positive T cell; INFLAMMATORY-BOWEL-DISEASE; MESALAZINE; GIRL;

D O I：

10.1007/s10157-010-0294-z

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Although drugs used in inflammatory bowel diseases (IBD) cause renal injury, glomerulopathies may also accompany IBD. We report a case with the rare association of ulcerative colitis (UC) and acute progressive interstitial nephritis. Although the kidney is acknowledged as a target organ for injury as a result of drug nephrotoxicity, our findings lend support to the novel recognition that the deranged autoimmune system emerging in UC causes interstitial nephritis as an extraintestinal manifestation. Overt renal failure due to interstitial nephritis has rarely been reported in UC patients. The case presented here therefore provides novel information on UC-associated nephropathy.

引用

页码：483 / 486

页数：4

共 13 条

[1] Interstitial nephritis from mesalazine: Case report and literature review [J].

Arend, LJ ;

Springate, JE .

PEDIATRIC NEPHROLOGY, 2004, 19 (05) :550-553

[2] Relationship of extraintestinal involvements in inflammatory bowel disease - New insights into autoimmune pathogenesis [J].

Das, KM .

DIGESTIVE DISEASES AND SCIENCES, 1999, 44 (01) :1-13

[3] 5-aminosalicylates and renal function in inflammatory bowel disease:: A systematic review [J].

Gisbert, Javier P. ;

Gonzalez-Lama, Yago ;

Mate, Jose .

INFLAMMATORY BOWEL DISEASES, 2007, 13 (05) :629-638

[4] Minimal renal dysfunction in inflammatory bowel disease is related to disease activity but not to 5-ASA use [J].

Herrlinger, KR ;

Noftz, MK ;

Fellermann, K ;

Schmidt, K ;

Steinhoff, J ;

Stange, EF .

ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2001, 15 (03) :363-369

[5] Tubulointerstitial disease and ulcerative colitis [J].

Khosroshahi, Hamid T. ;

Shoja, Mohammadali Mohajel .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2006, 21 (08) :2340-2340

[6]

KREISEK W, 2001, EUR J GASTROEN HEPAT, V8, P461

[7] NEPHROTIC SYNDROME IN ULCERATIVE-COLITIS [J].

NAND, N ;

WARD, MK ;

MORLEY, AR .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 1991, 6 (03) :227-227

[8] MECHANISMS OF DISEASE Inflammatory Bowel Disease [J].

Abraham, Clara ;

Cho, Judy H. .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (21) :2066-2078

[9] Late onset interstitial nephritis associated with mesalazine treatment [J].

Popoola, J ;

Muller, AF ;

Pollock, L ;

O'Donnell, P ;

Carmichael, P ;

Stevens, P .

BRITISH MEDICAL JOURNAL, 1998, 317 (7161) :795-797

[10] Autoimmune disorders and extraintestinal manifestations in first-degree familial and sporadic inflammatory bowel disease - A case-control study [J].

Ricart, E ;

Panaccione, R ;

Loftus, EV ;

Tremaine, WJ ;

Harmsen, WS ;

Zinsmeister, AR ;

Sandborn, WJ .

INFLAMMATORY BOWEL DISEASES, 2004, 10 (03) :207-214

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