Cu/Pd-Catalyzed One-Pot Synthesis of 2-(1,2,3-Triazolyl)methyl-3-alkynylImidazo[1,2-a]pyridines Involving Sequential SN Reaction/[3+2] Cycloaddition/Sonogashira Coupling Reactions

被引：1

作者：

El Qami, Abdelkarim ^{[1
,2
]}

Jismy, Badr ^{[1
]}

El Hakmaoui, Ahmed ^{[2
]}

Akssira, Mohamed ^{[2
]}

Abarbri, Mohamed ^{[1
]}

机构：

[1] Univ Tours, Dept Chem, Lab Phys Chim Mat & Electrolytes Energie PCM2E, Fac Sci,EA 6299, Ave Monge,Parc Grandmt, F-37200 Tours, France

[2] Univ Hassan II Casablanca, Lab Chim Phys & Chim Bioorgan, URAC 22 BP,146, Casablanca 28800, Mohammedia, Morocco

来源：

CHEMISTRYSELECT | 2021年 / 6卷 / 35期

关键词：

Click chemistry; Cross-coupling; CuAAC; Imidazo[1; 2-a]pyridine; One-pot synthesis; EFFICIENT SYNTHESIS; ZOLPIDEM; 1,2,3-TRIAZOLES; ALPIDEM; ACCESS; AGENTS; ACID;

D O I：

10.1002/slct.202102228

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient one-pot regioselective synthesis of 2-(1,2,3-triazolyl)methyl-3-alkynyl imidazo[1,2-a]pyridines is reported under simple and mild reaction conditions. The new imidazo[1,2-a]pyridines embedded with 4-substituted-[1,2,3]-triazole were obtained in good to excellent yields from 2-(chloromethyl)-3-iodo imidazo[1,2-a]pyridines via a one-pot sequence involving an SN reaction with azide, followed by copper-catalyzed [3+2]cycloaddition and a Sonogashira coupling reaction.

引用

收藏

页码：9415 / 9420

页数：6

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