Effect of CMV and HIV Transcription on CD57 and PD-1 T-Cell Expression During Suppressive ART

被引：15

作者：

Dan, Jennifer M. ^{[1
,2
,3
]}

Massanella, Marta ^{[2
]}

Smith, Davey M. ^{[2
,3
]}

Spina, Celsa A. ^{[2
,3
]}

Schrier, Rachel ^{[2
]}

Daar, Eric S. ^{[4
]}

Dube, Michael P. ^{[5
]}

Morris, Sheldon R. ^{[2
]}

Gianella, Sara ^{[2
]}

机构：

[1] La Jolla Inst Allergy & Immunol, La Jolla, CA USA

[2] Univ Calif San Diego, San Diego, CA 92103 USA

[3] Vet Affairs San Diego Healthcare Syst, San Diego, CA USA

[4] Harbor UCLA Med Ctr, Los Angeles Biomed Res Inst, Torrance, CA 90509 USA

[5] Univ So Calif, Keck Sch Med, Los Angeles, CA 90033 USA

来源：

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2016年 / 72卷 / 02期

关键词：

CMV; immune exhaustion; immune senescence; PD-1; CD57; ANTIRETROVIRAL THERAPY; IMMUNE ACTIVATION; INFECTION; CD4(+); IMMUNOSENESCENCE; PERSISTENCE; MECHANISMS; EXHAUSTION; MORTALITY; DYNAMICS;

D O I：

10.1097/QAI.0000000000000936

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

HIV-infected men who have sex with men are nearly universally coinfected with cytomegalovirus (CMV). In this study of 45 HIV-infected men who have sex with men virologically suppressed on ART, we found that presence of seminal CMV DNA shedding and higher levels of systemic cellular HIV RNA transcription were both independently associated with increased PD-1 expression on circulating CD4(+) T cells, but not with higher levels of senescent (CD57(+)) T cells. In addition, greater HIV RNA transcription was associated with lower CD57 expression on CD8 T cells. Although causality cannot be inferred from this retrospective study, these results suggest that asymptomatic CMV replication and residual cellular HIV transcription may contribute to persistent immune dysregulation during suppressive ART.

引用

页码：133 / 137

页数：5

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