Ruthenium-Catalyzed Conjugate Hydrogenation of α,β-Enones by in situ Generated Dihydrogen from Paraformaldehyde and Water

被引：33
|
作者：
Li, Wanfang [1 ]
Wu, Xiao-Feng [1 ]
机构：
[1] Univ Rostock, Leibniz Inst Katalyse EV, D-18059 Rostock, Germany
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 2015卷 / 02期
关键词：
Ruthenium; Water chemistry; Hydrogenation; Enones; Paraformaldehyde; ALPHA; BETA-UNSATURATED KETONES; HYDROFORMYLATION; FORMALDEHYDE; ALDEHYDES; OXIDATION; DERIVATIVES; REDUCTION; ALCOHOLS; ALLENES; OLEFINS;
D O I：
10.1002/ejoc.201403359
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Notwithstanding that the highly selective hydrogenation of alpha,beta-enones to allylic alcohols can be realized by using Noyori's Ru bifunctional system, the selective reduction of the C=C bonds in alpha,beta-enones without touching the C=O bonds still lacks a general, simple, and efficient procedure. Ruthenium-catalyzed conjugate hydrogenation of various alpha,beta-enones to saturated ketones with high selectivity was investigated. The most important feature of this procedure was that hydrogen in situ generated from paraformaldehyde (or formalin) and water was employed as the reductant.
引用
收藏
页码：331 / 335
页数：5
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