The effect of neurodegenerative diseases on the subventricular zone

被引：140

作者：

Curtis, Maurice A.

Faull, Richard L. M.

Eriksson, Peter S.

机构：

[1] Inst Neurosci & Physiol Sahlgrenska Acad, S-40530 Gothenburg, Sweden

[2] Univ Auckland, Fac Med & Hlth Sci, Dept Anat Radiol, Auckland 92019, New Zealand

来源：

NATURE REVIEWS NEUROSCIENCE | 2007年 / 8卷 / 09期

关键词：

NEURAL STEM-CELLS; EPIDERMAL-GROWTH-FACTOR; NEURONAL PROGENITOR CELLS; ROSTRAL MIGRATORY STREAM; NEWLY GENERATED NEURONS; TRANSGENIC MOUSE MODEL; MEDIATED GENE-TRANSFER; AMYLOID BETA-PEPTIDE; RAT DENTATE GYRUS; ADULT HUMAN BRAIN;

D O I：

10.1038/nrn2216

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

During brain development, one of the most important structures is the subventricular zone ( SVZ), from which most neurons are generated. In adulthood the SVZ maintains a pool of progenitor cells that continuously replace neurons in the olfactory bulb. Neurodegenerative diseases induce a substantial upregulation or downregulation of SVZ progenitor cell proliferation, depending on the type of disorder. Far from being a dormant layer, the SVZ responds to neurodegenerative disease in a way that makes it a potential target for therapeutic intervention.

引用

收藏

页码：712 / 723

页数：12

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