The effect of neurodegenerative diseases on the subventricular zone

被引:140
作者
Curtis, Maurice A.
Faull, Richard L. M.
Eriksson, Peter S.
机构
[1] Inst Neurosci & Physiol Sahlgrenska Acad, S-40530 Gothenburg, Sweden
[2] Univ Auckland, Fac Med & Hlth Sci, Dept Anat Radiol, Auckland 92019, New Zealand
关键词
NEURAL STEM-CELLS; EPIDERMAL-GROWTH-FACTOR; NEURONAL PROGENITOR CELLS; ROSTRAL MIGRATORY STREAM; NEWLY GENERATED NEURONS; TRANSGENIC MOUSE MODEL; MEDIATED GENE-TRANSFER; AMYLOID BETA-PEPTIDE; RAT DENTATE GYRUS; ADULT HUMAN BRAIN;
D O I
10.1038/nrn2216
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
During brain development, one of the most important structures is the subventricular zone ( SVZ), from which most neurons are generated. In adulthood the SVZ maintains a pool of progenitor cells that continuously replace neurons in the olfactory bulb. Neurodegenerative diseases induce a substantial upregulation or downregulation of SVZ progenitor cell proliferation, depending on the type of disorder. Far from being a dormant layer, the SVZ responds to neurodegenerative disease in a way that makes it a potential target for therapeutic intervention.
引用
收藏
页码:712 / 723
页数:12
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