Promoter Methylation Status of Multidrug Resistance 1 (MDR1) Gene in Noncancerous Gastric Mucosa Correlates With Helicobacter Pylori Infection and Gastric Cancer Occurrence

被引：7

作者：

Tahara, Tomomitsu ^{[1
]}

Shibata, Tomoyuki ^{[1
]}

Yamashita, Hiromi ^{[1
]}

Yoshioka, Daisuke ^{[1
]}

Hirata, Ichiro ^{[1
]}

Arisawa, Tomiyasu ^{[2
]}

机构：

[1] Fujita Hlth Univ, Sch Med, Dept Gastroenterol, Toyoake, Aichi 47011, Japan

[2] Kanazawa Med Univ, Dept Gastroenterol, Kanazawa, Ishikawa, Japan

来源：

CANCER INVESTIGATION | 2010年 / 28卷 / 07期

关键词：

MDR1; Methylation; Gastric cancer; ABERRANT DNA METHYLATION; P-GLYCOPROTEIN; PROLIFERATIVE ACTIVITY; BREAST-CANCER; HEPATITIS-B; EXPRESSION; HYPERMETHYLATION; ERADICATION; APOPTOSIS; OVEREXPRESSION;

D O I：

10.3109/07357907.2010.483505

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We investigated the methylation status of multidrug resistance 1 (MDR1) gene promoter in noncancerous gastric mucosa in relation to gastric cancer (GC) occurrence. Methylation of the MDR1 promoter was estimated in 127 GC and 82 non-GC patients. A significant association was found between higher methylation ratio and occurrence of GC. Higher methylation ratio was also associated with occurrence of GC in both Helicobacter pylori-positive and Helicobacter pylori-negative subjects. Higher MR was also associated with Helicobacter pylori infection. Methylation status of MDR1 gene in noncancerous gastric mucosa would be useful for predicting GC occurrence.

引用

页码：711 / 716

页数：6

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