Facile synthesis and biological evaluation of chrysin derivatives

被引：8

作者：

Omonga, Nicholas ^{[1
]}

Zia, Zakia ^{[2
]}

Ghanbour, Hesham ^{[1
]}

Ragazzon-Smith, Abby ^{[3
]}

Foster, Howard ^{[1
]}

Hadfield, John ^{[1
]}

Ragazzon, Patricia ^{[4
]}

机构：

[1] Univ Salford, Biomed Res Ctr, Sch Sci Engn & Environm, Salford, Lancs, England

[2] Labcorp Clin Res Unit Ltd, Leeds, W Yorkshire, England

[3] Manchester Metropolitan Univ, Sch Sci & Environm, Manchester, Lancs, England

[4] Keele Univ, Sch Pharm & Bioengn, Hornbeam 2-26, Keele ST5 BG, Staffs, England

来源：

JOURNAL OF CHEMICAL RESEARCH | 2021年 / 45卷 / 11-12期

关键词：

antibacterial; antifungal; chrysin derivatives; cytotoxicity; microwave; ANTIMICROBIAL RESISTANCE; INFECTION; APOPTOSIS; DESIGN; ENTEROBACTERIACEAE; MECHANISMS; FLAVONOIDS; CELLS;

D O I：

10.1177/17475198211057467

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this paper, novel synthetic methods, including microwave O-alkylation, were used to produce several chrysin derivatives. These compounds were purified, characterised and tested on different cell lines and bacterial strains. From this family, 7-(2,4-dinitrophenoxy)-5-hydroxy-3-phenyl-4H-chromen-4-one (C3) was shown to be extremely active on bacterial strains methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa and Klebsiella pneumoniae as well as having anticancer activity on a range of cancer cell lines with IC50 values less than 30 mu M. Chrysin has been known for their anticancer and antimicrobial properties, and this study not only corroborates this but also shows that it is possible to synthesise new improved derivatives with therapeutic possibilities.

引用

页码：1083 / 1092

页数：10

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